Intro; Foreword; Preface; Contents; Contributors; Chapter 1: Prostate Cancer Screening in African-­American Men; Diagnosis and Screening; Evaluation; Management; Conclusion; References; Chapter 2: Evaluation and Treatment for Older Men with Elevated PSA; PSA Screening and USPSTF Recommendations; Impact of USPSTF Recommendations; Overdiagnosis and Overtreatment; Life Expectancy Tools; Assessment of Cancer Risk; Alternatives to PSA-Based Screening: Biomarkers; PSA Derivatives; Free PSA; Prostate Health Index; 4Kscore; Prostate Cancer Antigen 3; Predictive Nomograms; Prostate MRI

Special Considerations in Elderly PatientsAn Optimized Diagnostic Approach; Conclusions; References; Chapter 3: Utilizing Biomarkers in Patients with Prior Negative Prostate Biopsy; Current Clinical Information; Free PSA; Prostate Health Index; Kallikrein Panel (4Kscore); Prostate Cancer Antigen 3 (PCA3); DNA Methylation Assays (ConfirmMDx); Current Guidelines and Future Directions; Summary; References; Chapter 4: Active Surveillance in African-Americans; Evaluation and Guidelines; Racial Differences in Prostate Cancer Burden and Mortality

Should African American Men Be Eligible for Active Surveillance?Considerations for Choosing Active Surveillance; Conclusions; References; Chapter 5: Focal Therapy Versus Surveillance in Intermediate-Risk Cancer; Screening; Diagnosis; Evaluation; Therapeutic Management; Active Surveillance; Focal Therapy; Conclusions; References; Chapter 6: Prostate Cancer Treatment Options for Men with Significant Urinary Symptoms and Enlarged Prostates; Evaluation; Therapeutic Management; Conclusion; References; Chapter 7: Adjuvant Radiation Therapy for High-­Risk Post-prostatectomy Patients

Pre-prostatectomy Patient EvaluationPost-prostatectomy Patient Evaluation; Post-prostatectomy Radiation Therapy; Adjuvant Radiation Therapy; Salvage Radiation Therapy; Selective Treatment Intensification with Post-prostatectomy Radiation Therapy; Future Directions; Conclusions and Recommendations for Presented Clinical Case; References; Chapter 8: Biochemical Recurrence After Radiation Therapy; Screening/Surveillance; Recurrence Risk; Concurrent Androgen Deprivation Therapy; PSA Kinetics; Disease-Specific Risk; Surveillance Schedule; Diagnosis; Variation Between Radiation and Surgery

Benign Prostate TissuePSA Bounce; Biochemical Recurrence Definition; Historical/Alternative Criteria; Phoenix Criteria; Evaluation; Sites of Recurrence; Traditional Evaluation; Imaging Evaluation; Bone Imaging; CT Scan/MRI; Role of Biopsy; Emerging/Advanced Imaging; Therapeutic Management; Localized Salvage Treatment; Considerations; Observation; Salvage Prostatectomy; Salvage Radiation; Salvage Cryoablation; Salvage HIFU; Distant Salvage Treatment; Treatment of Oligometastatic Disease with Radiation or Surgical Excision; Systemic Treatment Options; Androgen Deprivation Therapy; Conclusion