000839455 000__ 06498cam\a2200529Ii\4500 000839455 001__ 839455 000839455 005__ 20230306144649.0 000839455 006__ m\\\\\o\\d\\\\\\\\ 000839455 007__ cr\un\nnnunnun 000839455 008__ 180529t20182018sz\\\\\\ob\\\\000\0\eng\d 000839455 019__ $$a1038478247$$a1039062242$$a1040612537 000839455 020__ $$a9783319767505$$q(electronic book) 000839455 020__ $$a331976750X$$q(electronic book) 000839455 020__ $$z9783319767499 000839455 020__ $$z3319767496 000839455 0247_ $$a10.1007/978-3-319-76750-5$$2doi 000839455 035__ $$aSP(OCoLC)on1037945811 000839455 035__ $$aSP(OCoLC)1037945811$$z(OCoLC)1038478247$$z(OCoLC)1039062242$$z(OCoLC)1040612537 000839455 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dGW5XE$$dEBLCP$$dYDX$$dAZU$$dUAB$$dOCLCF$$dOCLCQ 000839455 049__ $$aISEA 000839455 050_4 $$aQ180.55.M3 000839455 08204 $$a507.2$$223 000839455 1001_ $$aLanati, Antonella,$$eauthor. 000839455 24510 $$aQuality management in scientific research :$$bchallenging irreproducibility of scientific results /$$cAntonella Lanati. 000839455 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2018] 000839455 264_4 $$c©2018 000839455 300__ $$a1 online resource. 000839455 336__ $$atext$$btxt$$2rdacontent 000839455 337__ $$acomputer$$bc$$2rdamedia 000839455 338__ $$aonline resource$$bcr$$2rdacarrier 000839455 347__ $$atext file$$bPDF$$2rda 000839455 504__ $$aIncludes bibliographical references. 000839455 5050_ $$aIntro; Foreword; Contents; Abbreviations; 1: Introduction; 1.1 Acknowledgements; 1.2 Permissions; References; 2: How Quality Can Improve Reproducibility; 2.1 The Unknown of Reproducibility; 2.1.1 Irreproducibility and Retractions; 2.1.2 The Economics of Poor Reproducibility; 2.1.3 Reasons and Solutions; 2.2 What Is Quality; 2.3 Quality for Research; 2.4 Research Integrity; References; 3: Principles, References and Standards; 3.1 Quality Basics; 3.2 Total Quality Management; 3.2.1 The Process Approach; 3.2.2 Principles; 3.2.3 PDCA Cycle; 3.2.4 The Requirements 000839455 5058_ $$a3.3 Quality Certification and Accreditation3.4 Quality Standards for Certification in Scientific Research; 3.4.1 ISO 9000; 3.4.2 Good Laboratory Practice; 3.4.3 ISO/IEC 17025; 3.4.4 Other References; References; 4: Quality and Basic Biomedical Research; 4.1 What Is Basic Biomedical Research; 4.2 Conscious Management; 4.3 Quality Throughout the Research Project; 4.3.1 Management of Study Contents and Controls; 4.3.1.1 Initial Requirements; 4.3.1.2 Controls and Metrics; 4.3.1.3 Documentation; 4.3.1.4 Training; 4.3.1.5 Communication; 4.3.1.6 Procurement 000839455 5058_ $$a4.3.2 Management of the Research Project4.3.2.1 Planning; 4.3.2.2 Executing and Measuring; 4.3.2.3 Exploiting; 4.3.2.4 The Importance of Planned Controls (Shannon Eaker ); 4.4 International References and Models; 4.4.1 WHO-TDR Handbook on Quality Practices in Basic Biomedical Research; 4.4.2 Joint Code of Practice for Research: JCoPR (UK); 4.4.3 Research Quality Association Handbook and Guidelines; 4.4.4 Other Examples; 4.5 Quality Management in Basic Biomedical Research; 4.5.1 Organisation; 4.5.1.1 Quality Policy and Objectives; 4.5.1.2 Organisational Chart and Job Description 000839455 5058_ $$a4.5.2 Quality System4.5.2.1 Quality Assurance and Quality Control; 4.5.2.2 Research Reviews; 4.5.3 Personnel; 4.5.3.1 Responsibility; 4.5.3.2 Competence, Skills and Motivation; 4.5.4 Physical Resources; 4.5.4.1 Economics; 4.5.4.2 Facilities; 4.5.4.3 Equipment; 4.5.4.4 Products for the Research; 4.5.4.5 Computer Systems; 4.5.5 Validation; 4.5.5.1 Protocols and Assay Validation; 4.5.5.2 Result Validation; 4.5.6 Documentation; 4.5.6.1 Prescriptive Documents; 4.5.6.2 Descriptive Documents; 4.5.6.3 Study Report; 4.5.7 Storage and Archiving; 4.5.7.1 Data Archiving 000839455 5058_ $$a4.5.7.2 Sample Storage4.5.8 Health and Safety; 4.5.9 Publishing Practices; 4.5.10 Ethics; 4.6 Examples of Application; 4.6.1 Managing Research Resources in a Large Institute: The San Raffaele Experience (Daniele Zacchetti ); 4.6.2 A QMS for a Life Sciences Research Laboratory and Its Related Management Software (the qPMO WP3 Team ); 4.6.3 GLP as a Reference for Non-regulated Research (the MoBiLab Team ); References; 5: Quality Tools for the Scientific Research; 5.1 Tools for Project and Process Quality; 5.2 7 Basic Tools of TQM; 5.2.1 Pareto Chart 000839455 506__ $$aAccess limited to authorized users. 000839455 520__ $$aIn recent years, the attention of the scientific and social community has not solely been on producing new findings, but increasingly also on the related issues of the reliability, safety, and efficacy of the discoveries made, as well as the efficient and effective use of resources. The adoption of management models and tools can help scientists to improve their research, ensuring valuable, robust and dependable outcomes. Quality disciplines have been widely used for decades in industrial and business fields, building a knowledge base that can be translated and exploited, much to the advantage of scientific research. However, quality references in scientific research are still extremely rare and largely limited to an international guideline and a few sector-specific standards. Despite WHO and EU Commission campaigns, there are still precious few practical texts that offer researchers guidance on quality principles and provide simple tools and methodologies for their daily work. The book, starting from the problem of the reproducibility of scientific results and the substantial contribution that the Quality approach can make to research (Chapter 1), introduces the reader to key principles and basic concepts of Quality and illustrates both general and research-specific quality standards, paving the way for further discussion (Chapter 2). In turn, Chapter 3 presents detailed applications of Quality principles in various aspects of research, from study and ethics to materials and equipment management. Chapters 4 and 5, respectively, are devoted to Quality tools and Quality methodologies, as well as soft skills, all of which are valuable to scientific experimentation and study management. The concepts and practical tools discussed are extensively illustrated with examples from actual applications in scientific research. 000839455 588__ $$aOnline resource; title from PDF title page (viewed May 30, 2018). 000839455 650_0 $$aResearch$$xManagement. 000839455 650_0 $$aResearch$$xQuality control. 000839455 77608 $$iPrint version: $$z3319767496$$z9783319767499$$w(OCoLC)1022084588 000839455 852__ $$bebk 000839455 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-76750-5$$zOnline Access$$91397441.1 000839455 909CO $$ooai:library.usi.edu:839455$$pGLOBAL_SET 000839455 980__ $$aEBOOK 000839455 980__ $$aBIB 000839455 982__ $$aEbook 000839455 983__ $$aOnline 000839455 994__ $$a92$$bISE