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000839462 019__ $$a1038057980$$a1040628808
000839462 020__ $$a9781137469106$$q(electronic book)
000839462 020__ $$a1137469102$$q(electronic book)
000839462 020__ $$z9781137475527
000839462 0247_ $$a10.1057/978-1-137-46910-6$$2doi
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000839462 049__ $$aISEA
000839462 050_4 $$aR850
000839462 08204 $$a610.72$$223
000839462 1001_ $$aMeskus, Mianna,$$eauthor.
000839462 24510 $$aCraft in biomedical research :$$bthe iPS cell technology and the future of stem cell science /$$cMianna Meskus.
000839462 264_1 $$aNew York :$$bPalgrave Macmillan,$$c[2018].
000839462 264_4 $$c©2018
000839462 300__ $$a1 online resource :$$billustrations.
000839462 336__ $$atext$$btxt$$2rdacontent
000839462 337__ $$acomputer$$bc$$2rdamedia
000839462 338__ $$aonline resource$$bcr$$2rdacarrier
000839462 347__ $$atext file$$bPDF$$2rda
000839462 504__ $$aIncludes bibliographical references and index.
000839462 5050_ $$aIntro; Acknowledgments; Contents; Abbreviations; List of Figures; Chapter 1: Introduction; The Perspectives of the Study; A Crowded Field: Theorizing Stem Cells; Science as Material Relations; The Issue of "Craft" in STS; Science as Craftwork; References; Part I: Clinical Translation; Chapter 2: Human Cells to the Market; Bioindustrialization; Biological Medicines and the European Union; Anticipatory Governance of Bioindustrialization; Evidence Labor; Conclusion; References; Chapter 3: Between Craft and Standardized Production; Translational Research: A View from the Laboratory
000839462 5058_ $$aCentralized Banking of iPS Cell LinesChallenges of Biobanking: To Deposit or Withhold?; Conclusion; References; Part II: Experimentation; Chapter 4: Making iPS Cells in the Laboratory; Scientific Craftwork and the Research Laboratory; Biological Dogma Reconfigured; Patient-Specific Starting Material; Reprogramming Cells; IPS Cells in Culture; Conclusion; References; Chapter 5: Instrumentality and Care in Experimental Research; Joining Repellent Concepts: Instrumentality and Care; Learning Through Experience; The Routine of Laboratory Labor; Affective Engagement as a Skill
000839462 5058_ $$aAutomation "Up to a Point"Conclusions; References; Part III: Tissue Donation; Chapter 6: Patients and the Material Origins of Knowledge; Clinical Labor and the Craft of Biomedicine; Becoming a Donor; Donor Accounts of Instrumentality and Care; Informed Consent as the Mediator of Experimentation; Researchers and Respected Cell Material; Conclusion; References; Chapter 7: Scientific Craftwork in the Age of Bioindustrialization; Challenges of Clinical Translation; Idiosyncratic Laboratory Labor; Patients, Scientists, and Cell Lines; The Ethnographer and Stakemaking; References; Index
000839462 506__ $$aAccess limited to authorized users.
000839462 520__ $$aThis book explores the new ways in which biology is becoming technology. The revolutionary iPS cell technology has made it possible to turn human skin and blood cells into pluripotent stem cells, thus providing an unprecedented opportunity to study the pathophysiology of diseases, understand human developmental biology, and generate new therapies. Drawing from a rich ethnographic study, Meskus traces the making of the iPS cell technology through the perspectives of clinical translation, laboratory experimentation, and tissue donation by voluntary patients. Discussing non-human agency, the embodied and affective basis of knowledge production, and the material politics of science, the book develops the idea of an instrumentality-care continuum as a fundamental dynamic of biomedical craft. This continuum, Meskus argues, opens up a novel perspective to the commercialization and industrial-scale appropriation of human biology, and thereby to the future of ethical biomedical research. .
000839462 588__ $$aVendor-supplied metadata.
000839462 650_0 $$aMedicine$$xResearch.
000839462 650_0 $$aBiology$$xResearch.
000839462 650_0 $$aMultipotent stem cells$$xResearch.
000839462 650_0 $$aStem cells$$xResearch.
000839462 77608 $$iPrint version: $$z9781137475527
000839462 852__ $$bebk
000839462 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1057/978-1-137-46910-6$$zOnline Access$$91397441.1
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