000839512 000__ 05380cam\a2200541Ii\4500 000839512 001__ 839512 000839512 005__ 20230306144733.0 000839512 006__ m\\\\\o\\d\\\\\\\\ 000839512 007__ cr\un\nnnunnun 000839512 008__ 180530s2018\\\\sz\\\\\\o\\\\\000\0\eng\d 000839512 019__ $$a1038398927$$a1039022292$$a1040612228$$a1041469715 000839512 020__ $$a9783319754741$$q(electronic book) 000839512 020__ $$a3319754742$$q(electronic book) 000839512 020__ $$z9783319754734 000839512 020__ $$z3319754734 000839512 0247_ $$a10.1007/978-3-319-75474-1$$2doi 000839512 035__ $$aSP(OCoLC)on1038016122 000839512 035__ $$aSP(OCoLC)1038016122$$z(OCoLC)1038398927$$z(OCoLC)1039022292$$z(OCoLC)1040612228$$z(OCoLC)1041469715 000839512 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dGW5XE$$dEBLCP$$dYDX$$dAZU$$dUAB$$dCOO$$dOCLCF$$dOCLCQ 000839512 049__ $$aISEA 000839512 050_4 $$aQR360 000839512 08204 $$a576.64$$223 000839512 24500 $$aActivation of viruses by host proteases /$$cEva Böttcher-Friebertschäuser, Wolfgang Garten, Hans Dieter Klenk, editors. 000839512 264_1 $$aCham :$$bSpringer,$$c2018. 000839512 300__ $$a1 online resource. 000839512 336__ $$atext$$btxt$$2rdacontent 000839512 337__ $$acomputer$$bc$$2rdamedia 000839512 338__ $$aonline resource$$bcr$$2rdacarrier 000839512 347__ $$atext file$$bPDF$$2rda 000839512 5050_ $$aIntro; Preface; Contents; Part I: Viral Proteins Activated By Host Proteases; 1: Activation of the Hemagglutinin of Influenza Viruses; 1.1 Structural Basis for Activation of HA Fusion Potential; 1.2 Structure of HA0 Cleavage Sites; 1.3 Activating Proteases; References; 2: Proteolytic Activation of Paramyxoviruses and Pneumoviruses; 2.1 Paramyxoviruses and Pneumoviruses; 2.2 The Role of Protease Cleavage in Fusion Protein Activation; 2.3 Proteases Involved in Paramyxovirus F Protein Proteolytic Cleavage; 2.3.1 Furin and Its Role in F Protein Cleavage 000839512 5058_ $$a2.3.2 Extracellular Cleavage of Paramyxovirus F Proteins with Monobasic Cleavage Sites2.3.3 The Henipavirus F proteins: Intracellular Cleavage by Endosomal Proteases; 2.4 Proteases Involved in Pneumovirus F Protein Proteolytic Cleavage; 2.4.1 Respiratory Syncytial Virus F Proteins: A Novel Case of Two Proteolytic Processing Events; 2.4.2 Extracellular Cleavage of F Proteins from the Metapneumoviruses; 2.5 F protein Proteolytic Processing, Pathogenesis, and Antiviral Approaches; 2.6 Proteolytic Activation of the Hemagglutinin-­Neuraminidase Glycoprotein; References 000839512 5058_ $$a3: Cleavage of the Glycoprotein of Arenaviruses3.1 Arenavirus Structure, Genome Organization, and Basic Virology; 3.2 Arenavirus GP Structure and Function; 3.3 The Proprotein Convertase SKI-1/S1P Cleaves Arenavirus GPC; 3.4 The Mechanism of SKI-1/S1P Processing of Arenavirus GPC Differs from Cellular Substrates; 3.5 Optimized Recognition of Arenavirus GPC by SKI-1/S1P: Viral Advantage and Achilles' Heel; 3.6 The Processing of Reptarenavirus GPC Is Largely Unknown; 3.7 Targeting SKI-1/S1P-Mediated GPC Processing as an Anti-arenaviral Strategy; 3.7.1 Protein-Based Strategies 000839512 5058_ $$a3.7.2 Peptide-Based Compounds and Small Molecules3.7.3 A Novel Cell-Based Sensor for SKI-1/S1P as a Platform for High-Throughput Drug Screening; 3.7.4 Use of the SKI-1/S1P Sensor to Predict Protease Use of Newly Emerging Arenaviruses; References; 4: Priming Time: How Cellular Proteases Arm Coronavirus Spike Proteins; 4.1 Introduction; 4.2 The Coronavirus Spike Protein: Viral Key for Entry into the Target Cell; 4.3 Proteolytic Priming of Coronavirus Spike Proteins: Basic Concepts; 4.4 Proteolytic Activation of the Spike Proteins of SARS-­CoV and MERS-CoV 000839512 5058_ $$a4.4.1 Cathepsin L: Endosomal Activator of the Spike Protein4.4.2 Activation of the Spike Protein by Type II Transmembrane Serine Proteases at the Cell Surface; 4.4.3 Furin Can Activate Coronavirus Spike Proteins in the Constitutive Secretory Pathway of Infected Cells and During Viral Entry into Target Cells; References; 5: Proteolytic Processing of Filovirus Glycoproteins; 5.1 Introduction; 5.2 Biosynthesis and Maturation of Filovirus Glycoproteins; 5.3 The Role of GP in Host Cell Entry; 5.4 Proteases Responsible for GP Processing; References 000839512 506__ $$aAccess limited to authorized users. 000839512 520__ $$aThis book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship. 000839512 588__ $$aOnline resource; title from PDF title page (viewed May 31, 2018) 000839512 650_0 $$aViruses. 000839512 650_0 $$aImmunology. 000839512 650_0 $$aProteolytic enzymes. 000839512 7001_ $$aBöttcher-Friebertshäuser, E.,$$eeditor. 000839512 7001_ $$aGarten, Wolfgang,$$eeditor. 000839512 7001_ $$aKlenk, H.-D.$$q(Hans-Dieter),$$d1938-$$eeditor. 000839512 77608 $$iPrint version: $$z3319754734$$z9783319754734$$w(OCoLC)1019642287 000839512 852__ $$bebk 000839512 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-75474-1$$zOnline Access$$91397441.1 000839512 909CO $$ooai:library.usi.edu:839512$$pGLOBAL_SET 000839512 980__ $$aEBOOK 000839512 980__ $$aBIB 000839512 982__ $$aEbook 000839512 983__ $$aOnline 000839512 994__ $$a92$$bISE