000843364 000__ 05457cam\a2200541Ii\4500 000843364 001__ 843364 000843364 005__ 20230306144720.0 000843364 006__ m\\\\\o\\d\\\\\\\\ 000843364 007__ cr\cn\nnnunnun 000843364 008__ 180605s2018\\\\sz\a\\\\o\\\\\000\0\eng\d 000843364 019__ $$a1040616396$$a1043001846 000843364 020__ $$a9783319898780$$q(electronic book) 000843364 020__ $$a3319898787$$q(electronic book) 000843364 020__ $$z9783319898773 000843364 0247_ $$a10.1007/978-3-319-89878-0$$2doi 000843364 035__ $$aSP(OCoLC)on1038721281 000843364 035__ $$aSP(OCoLC)1038721281$$z(OCoLC)1040616396$$z(OCoLC)1043001846 000843364 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dN$T$$dEBLCP$$dAZU$$dUPM$$dOCLCF$$dUAB 000843364 049__ $$aISEA 000843364 050_4 $$aRC254.5 000843364 08204 $$a616.99/4$$223 000843364 24500 $$aNanooncology :$$bengineering nanomaterials for cancer therapy and diagnosis /$$cGil Gonçalves, Gerard Tobias, editors. 000843364 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018. 000843364 300__ $$a1 online resource (vi, 455 pages) :$$billustrations. 000843364 336__ $$atext$$btxt$$2rdacontent 000843364 337__ $$acomputer$$bc$$2rdamedia 000843364 338__ $$aonline resource$$bcr$$2rdacarrier 000843364 347__ $$atext file$$bPDF$$2rda 000843364 4901_ $$aNanomedicine and nanotoxicology,$$x2194-0452 000843364 5050_ $$aIntro; Contents; Gold Nanoparticles for Imaging and Cancer Therapy; 1 Introduction; 2 Synthesis of Gold Nanoparticles for Biomedical Applications; 2.1 Direct Reduction: The Turkevitch Method; 2.2 Seed-Mediated Growth for Smaller and Narrower Particle Size Distributions; 2.3 Syntheses Taking Place in Organic Media; 2.4 Au NPs Purification Prior to Coatings and Functionalization; 2.5 Ligand-Free Au NP Suspensions; 2.6 Surface Treatment of Au NPs; 2.7 Cell Toxicity of Au NPs: In Vitro Studies; 3 Principles of Physical Interactions Between Photons and High-Z Elements 000843364 5058_ $$a4 Impact of Radiation and Au-Mediated Radiosensitization Products on Cells and Tissues4.1 The Physical Phase; 4.2 The Chemical Phase; 4.3 Measurement of Physical and Chemical Impact of Au NPs on DNA; 4.4 The Biological Phase; 5 Performance of Au NPs as X-Ray Computed Tomography Contrast Agents; 5.1 Attenuation of X-Rays by High-Z Elements; 5.2 Conventional Iodinated Contrast Agents; 5.3 Blood-Pool Contrast Agents; 5.4 Au-Based Blood-Pool Agents; 6 Performance of Gold Nanoparticles as Radiosensitizers in Oncology; 6.1 Main Mechanisms of Radiosensitization 000843364 5058_ $$a6.2 Au NPs as Radiosensitizers in External Beam Therapy6.3 Dose Simulations Have Confirmed a Good Match Between Au NPs and Brachytherapy Sources; 6.4 Radioactive Au NPs; 6.5 Current Status of Au NPs as Radiosensitizers for Clinical Applications; 7 Biodistribution, Clearance and in Vivo Toxicity; 7.1 Biodistribution and Clearance Routes of Gold Nanoparticles; 7.2 The Intravascular Injection Route; 7.3 The Intratumoral Injection Route; 7.4 In Vivo Toxicity Studies; 8 Perspectives: Current Status of Au NPs in Clinical Trials; 9 Conclusion; References 000843364 5058_ $$aLiposomes-Based Nanoparticles for Cancer Therapy and Bioimaging1 Introduction; 1.1 Liposome Composition; 2 Cancer Therapy; 2.1 Drug Delivery System; 2.2 Liposomes in Gene Delivery; 2.3 Targeted Delivery; 3 Bioimaging; 3.1 Image-Guided Drug Delivery; 4 Conclusion; References; Quantum Dots for Cancer Therapy and Bioimaging; 1 Semiconductor Quantum Dots; 1.1 QDs for Tumor Imaging; 1.2 QDs in Cancer Therapy; 1.3 Limitations and Future Perspectives; 2 Silver Chalcogenide Quantum Dots; 2.1 Silver Sulfide (Ag2S) QDs; 2.2 Silver Selenide (Ag2Se) QDs; 2.3 Silver Telluride (Ag2Te) QDs 000843364 5058_ $$a2.4 Limitations and Future Perspectives3 Carbon Quantum Dots; 3.1 CDs for Cancer Bioimaging; 3.2 CDs for Cancer Therapy; 4 Silicon Quantum Dots; 4.1 Silicon Quantum Dots for Bioimaging Applications; 4.2 Silicon Quantum Dots for Drug Delivery and Cancer Therapy; 5 Black Phosphorus Quantum Dots (BP QDs); 6 Germanium Quantum Dots (Ge QDs); 7 Semiconducting Polymer Dots; 7.1 Cancer Cell-Specific Imaging and in Vivo Tumor Imaging; 7.2 Pdots-Based Cancer Therapy; 7.3 Non-conjugated Pdots and Their Biomedical Applications; 8 Final Remarks and Future Perspective; References 000843364 506__ $$aAccess limited to authorized users. 000843364 520__ $$aThis book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases. 000843364 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed June 5, 2018). 000843364 650_0 $$aOncology$$xTechnological innovations. 000843364 650_0 $$aNanomedicine. 000843364 7001_ $$aGonçalves, Gil,$$eeditor. 000843364 7001_ $$aTobias, Gerard,$$eeditor. 000843364 77608 $$iPrint version: $$z9783319898773 000843364 830_0 $$aNanomedicine and nanotoxicology. 000843364 852__ $$bebk 000843364 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-89878-0$$zOnline Access$$91397441.1 000843364 909CO $$ooai:library.usi.edu:843364$$pGLOBAL_SET 000843364 980__ $$aEBOOK 000843364 980__ $$aBIB 000843364 982__ $$aEbook 000843364 983__ $$aOnline 000843364 994__ $$a92$$bISE