Rethinking platinum anticancer drug design : towards targeted and immuno-chemotherapeutic approaches / Danial Yuan Qiang Wong.

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Rethinking platinum anticancer drug design : towards targeted and immuno-chemotherapeutic approaches / Danial Yuan Qiang Wong.

9789811085949 (electronic book)
9811085943 (electronic book)
9789811085932
9811085935

Singapore : Springer, [2018]

©2018

English

1 online resource : illustrations (some color).

RC271.C5

616.99/4061

This thesis describes the authors’ pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these “secret allies” contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immune responses to malignancies, eliminating residual cancer cells.

"Doctoral thesis accepted by the National University of Singapore, Singapore."

Includes bibliographical references.

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Online resource ; title from PDF title page (viewed June 22, 2018).

Springer theses.

Print version: 9789811085932

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