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000843705 019__ $$a1042400048$$a1043399889
000843705 020__ $$a9783319926339$$q(electronic book)
000843705 020__ $$a3319926330$$q(electronic book)
000843705 020__ $$z9783319926322
000843705 020__ $$z3319926322
000843705 035__ $$aSP(OCoLC)on1041937715
000843705 035__ $$aSP(OCoLC)1041937715$$z(OCoLC)1042400048$$z(OCoLC)1043399889
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000843705 049__ $$aISEA
000843705 050_4 $$aR154.F655
000843705 08204 $$a610.92$$223
000843705 1001_ $$aRibatti, Domenico,$$d1956-$$eauthor.
000843705 24510 $$aJudah Folkman :$$ba biography /$$cDomenico Ribatti.
000843705 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018.
000843705 300__ $$a1 online resource.
000843705 336__ $$atext$$btxt$$2rdacontent
000843705 337__ $$acomputer$$bc$$2rdamedia
000843705 338__ $$aonline resource$$bcr$$2rdacarrier
000843705 504__ $$aIncludes bibliographical references.
000843705 5050_ $$aIntro; Abstract; Contents; Chapter 1: Biographic Profile; 1.1 Awards; References; Chapter 2: Development of Assays to Study Angiogenesis; 2.1 The Rabbit Cornea; 2.2 The Chorioallantoic Membrane; 2.3 Culture of Endothelial Cells; References; Chapter 3: Tumor Angiogenesis; 3.1 Early Evidence That Tumor Cells Release Specific Growth Factors for Endothelial Cells; 3.2 Absence of Angiogenesis in Tumors in Isolated Perfused Organs; 3.3 Tumor Growth Is Angiogenesis Dependent; 3.4 The Concept of Angiogenic Switch; 3.5 The Avascular and Vascular Phases of Solid Tumor Growth
000843705 5058_ $$a3.6 Angiogenesis and Metastasis3.7 Prognostic Significance of Tumor Vascularity; References; Chapter 4: The Discovery of Angiogenesis Factors; 4.1 Isolation of the First Tumor Angiogenic Tumor; 4.2 The Discovery of FGF; 4.3 The Discovery of VPF/VEGF; References; Chapter 5: Anti-angiogenesis; 5.1 Inhibition of Angiogenesis by a Diffusibile Factor from Cartilage; 5.2 Endogenous, Direct and Indirect Inhibitors; 5.3 Interferon Alpha; 5.4 Platelet Factor 4/Protamine; 5.5 Angiostatic Steroids; 5.6 Fumagillin; 5.7 Angiostatin and Endostatin; 5.8 Thalidomide
000843705 5058_ $$a5.9 2-Methoxyestradiol and Cleaved Antithrombin III5.10 Anti-angiogenic Chemotherapy; References; Chapter 6: Concluding Remarks; References; Chapter 7: Publications of Judah Folkman (2014-1956)
000843705 506__ $$aAccess limited to authorized users.
000843705 520__ $$aThe aim if this book is to analyze the scientific biography of Judah Folkman, one of the most important scientist of the last century. More 50 years ago, Folkman found a revolutionary new way to think about cancer. Blood supply, Folkman hypothesized, was the key to tumor growth. Without new blood vessels, tumors simply did not thrive. In 1971, Folkman published his theory of angiogenesis in the “New England Journal of Medicine”. Angiogenesis, the formation and recruitment of new blood vessels, is necessary for tumor growth. Critics of the theory were silenced over time as Folkman and his colleagues reported the first purified angiogenic molecule, the first angiogenesis inhibitor and proposed the concept of angiogenic disease. The mechanism of angiogenesis is now a worldwide field of investigation. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases.
000843705 588__ $$aOnline resource; title from PDF title page (viewed June 27, 2018).
000843705 60010 $$aFolkman, M. Judah.
000843705 650_0 $$aMedical scientists$$zUnited States$$vBiography.
000843705 650_0 $$aCancer$$xResearch.
000843705 650_0 $$aNeovascularization$$xResearch.
000843705 77608 $$iPrint version: $$z3319926322$$z9783319926322$$w(OCoLC)1033477470
000843705 852__ $$bebk
000843705 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-92633-9$$zOnline Access$$91397441.1
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000843705 980__ $$aEBOOK
000843705 980__ $$aBIB
000843705 982__ $$aEbook
000843705 983__ $$aOnline
000843705 994__ $$a92$$bISE