Judah Folkman : a biography / Domenico Ribatti.
Ribatti, Domenico, 1956- author.
2018
R154.F655
Available Online

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Title Judah Folkman : a biography / Domenico Ribatti.
Author Ribatti, Domenico, 1956- author.
ISBN 9783319926339 (electronic book)
3319926330 (electronic book)
9783319926322
3319926322
Published Cham, Switzerland : Springer, 2018.
Language English
Description 1 online resource.
Call Number R154.F655
Dewey Decimal Classification 610.92
Summary The aim if this book is to analyze the scientific biography of Judah Folkman, one of the most important scientist of the last century. More 50 years ago, Folkman found a revolutionary new way to think about cancer. Blood supply, Folkman hypothesized, was the key to tumor growth. Without new blood vessels, tumors simply did not thrive. In 1971, Folkman published his theory of angiogenesis in the “New England Journal of Medicine”. Angiogenesis, the formation and recruitment of new blood vessels, is necessary for tumor growth. Critics of the theory were silenced over time as Folkman and his colleagues reported the first purified angiogenic molecule, the first angiogenesis inhibitor and proposed the concept of angiogenic disease. The mechanism of angiogenesis is now a worldwide field of investigation. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (viewed June 27, 2018).
Available in Other Form Print version: 9783319926322
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Intro; Abstract; Contents; Chapter 1: Biographic Profile; 1.1 Awards; References; Chapter 2: Development of Assays to Study Angiogenesis; 2.1 The Rabbit Cornea; 2.2 The Chorioallantoic Membrane; 2.3 Culture of Endothelial Cells; References; Chapter 3: Tumor Angiogenesis; 3.1 Early Evidence That Tumor Cells Release Specific Growth Factors for Endothelial Cells; 3.2 Absence of Angiogenesis in Tumors in Isolated Perfused Organs; 3.3 Tumor Growth Is Angiogenesis Dependent; 3.4 The Concept of Angiogenic Switch; 3.5 The Avascular and Vascular Phases of Solid Tumor Growth

3.6 Angiogenesis and Metastasis3.7 Prognostic Significance of Tumor Vascularity; References; Chapter 4: The Discovery of Angiogenesis Factors; 4.1 Isolation of the First Tumor Angiogenic Tumor; 4.2 The Discovery of FGF; 4.3 The Discovery of VPF/VEGF; References; Chapter 5: Anti-angiogenesis; 5.1 Inhibition of Angiogenesis by a Diffusibile Factor from Cartilage; 5.2 Endogenous, Direct and Indirect Inhibitors; 5.3 Interferon Alpha; 5.4 Platelet Factor 4/Protamine; 5.5 Angiostatic Steroids; 5.6 Fumagillin; 5.7 Angiostatin and Endostatin; 5.8 Thalidomide

5.9 2-Methoxyestradiol and Cleaved Antithrombin III5.10 Anti-angiogenic Chemotherapy; References; Chapter 6: Concluding Remarks; References; Chapter 7: Publications of Judah Folkman (2014-1956)

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