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Molecular mechanisms of notch signaling / Tilman Borggrefe, Benedetto Daniele Giaimo, editors.

Borggrefe, Tilman, editor.; Giaimo, Benedetto Daniele, editor.
2018
QP517.C45
Available Online
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Title
Molecular mechanisms of notch signaling / Tilman Borggrefe, Benedetto Daniele Giaimo, editors.
ISBN
9783319895123 (electronic book)
3319895125 (electronic book)
9783319895116
3319895117
DOI
https://doi.org/10.1007/978-3-319-89512-3
Published
Cham, Switzerland : Springer, [2018]
Copyright
©2018
Language
English
Description
1 online resource (xxvii, 398 pages) : illustrations.
Item Number
10.1007/978-3-319-89512-3 doi
Call Number
QP517.C45
Dewey Decimal Classification
571.7/4
Summary
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments"--Publisher's description.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from electronic title page (SpringerLink, viewed July 24, 2018).
Added Author
Borggrefe, Tilman, editor.
Giaimo, Benedetto Daniele, editor.
Series
Advances in experimental medicine and biology ; v. 1066.
Available in Other Form
Print version: 9783319895116
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All Resources
Introduction to molecular mechanisms in notch signal transduction and disease pathogenesis / Benedetto Daniele Giaimo, Tilman Borggrefe
Molecular mechanisms of receptor/ligand interactions. Structural insights into notch receptor-ligand interactions / Penny A. Handford, Boguslawa Korona, Richard Suckling, Christina Redfield, Susan M. Lea
The molecular mechanism of notch activation / Klaus N. Lovendahl, Stephen C. Blacklow, Wendy R. Gordon
Regulation of notch function by O-glycosylation / Beth M. Harvey, Robert S. Haltiwanger
Modeling the notch response / Udi Binshtok, David Sprinzak
Endocytic trafficking of the notch receptor / Bj̲örn Schnute, Tobias Troost, Thomas Klein
Intracellular signaling mechanisms. The notch interactome: complexity in signaling circuitry / Diana M. Ho, K. G. Guruharsha, Spyros Artavanis-Tsakonas
Integration of drosophila and human genetics to understand notch signaling related diseases / Jose L. Salazar, Shinya Yamamoto
Mechanisms of non-canonical signaling in health and disease: diversity to take therapy up a notch? / Victor Alfred, Thomas Vaccari
The notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms / Diana Bellavia, Saula Checquolo, Rocco Palermo, Isabella Screpanti
Notch and neurogenesis / Anna Engler, Runrui Zhang, Verdon Taylor
Notch and stem cells / Anna Bigas, Cristina Porcheri
Oscillatory control of notch signaling in development / Ryoichiro Kageyama, Hiromi Shimojo, Akihiro Isomura
CSL-associated corepressor and coactivator complexes / Franz Oswald, Rhett A. Kovall
Disease links and therapeutics. Notch and senescence / Matthew Hoare, Masashi Narita
Control of blood vessel formation by notch signaling / Fabian Tetzlaff, Andreas Fischer
Notch and T cell function: a complex tale / Jyothi Vijayaraghavan, Barbara A. Osborne
Notch in leukemia / Anna C. McCarter, Qing Wang, Mark Chiang.

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