000844435 000__ 04463cam\a2200493Ii\4500 000844435 001__ 844435 000844435 005__ 20230306144842.0 000844435 006__ m\\\\\o\\d\\\\\\\\ 000844435 007__ cr\cn\nnnunnun 000844435 008__ 180801s2018\\\\sz\\\\\\o\\\\\000\0\eng\d 000844435 019__ $$a1047644927 000844435 020__ $$a9783319773094$$q(electronic book) 000844435 020__ $$a3319773097$$q(electronic book) 000844435 020__ $$z9783319773087 000844435 020__ $$z3319773089 000844435 035__ $$aSP(OCoLC)on1046977721 000844435 035__ $$aSP(OCoLC)1046977721$$z(OCoLC)1047644927 000844435 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dGW5XE$$dN$T$$dYDX$$dEBLCP 000844435 049__ $$aISEA 000844435 050_4 $$aQH591 000844435 08204 $$a571.6/5$$223 000844435 24500 $$aNuclear-cytoplasmic transport /$$cWeidong Yang, editor. 000844435 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018. 000844435 300__ $$a1 online resource. 000844435 336__ $$atext$$btxt$$2rdacontent 000844435 337__ $$acomputer$$bc$$2rdamedia 000844435 338__ $$aonline resource$$bcr$$2rdacarrier 000844435 4901_ $$aNucleic acids and molecular biology,$$x0933-1891 ;$$vvolume 33 000844435 5050_ $$aIntro; Contents; Chapter 1: Assembly of Nuclear Pore Complex; 1.1 Overview; 1.2 Nups and Subcomplexes of NPCs; 1.3 Assembly of NPCs; 1.3.1 NPC Assembly During Interphase; 1.3.2 Post-Mitotic NPC Assembly; 1.3.3 A Third Pathway for NPC Assembly; 1.4 Regulation of NPC Assembly; 1.5 Conclusions; References; Chapter 2: Structure of Yeast Nuclear Pore Complexes; 2.1 Introduction; 2.1.1 Overall Structure of the NPC; 2.1.2 Difference Between Yeast NPCs and Vertebrate NPCs; 2.2 Stoichiometry of Nups in Yeast NPC; 2.2.1 Recent Progress of the Stoichiometry of Nups by Several Approaches 000844435 5058_ $$a2.2.2 Stoichiometry of Nups in Living Yeast NPCby a Single Molecular Detection Approach2.3 Dynamics of Nups; 2.4 Perspective; References; Chapter 3: Dynamic Structures of the Nuclear Pore Complex and Their Roles in Nucleocytoplasmic Transport; 3.1 Introduction: The NPC Consists of a Rigid Scaffold and Dynamic Peripheral and Central Structures; 3.2 Structural Composition of Dynamic Components of the Nuclear Pore Complex; 3.2.1 The Cytoplasmic Face; 3.2.1.1 Nup358 Is the Major Component of the Cytoplasmic Filaments 000844435 5058_ $$a3.2.1.2 Nup214 and Nup88 Are Components of the Cytoplasmic Ring, not the Filaments3.2.1.3 Nup358/Cytoplasmic Filaments Are Anchored to Nup96 and Nup133 of the Y Complex; 3.2.1.4 Nup358 Is a Multidomain Platform; 3.2.1.5 Nup358 Is Dynamic; 3.2.1.6 Yeast and Plants Have Cytoplasmic Filaments but not Nup358; 3.2.2 FG Domains; 3.2.2.1 Cytosol Is Excluded from an FG Domain-Containing Region Around the NPC Entrance; 3.2.2.2 FG Domains Adopt Alternative Conformations; 3.2.2.3 FG Domains May Form Specific but Dynamic Structures; 3.2.2.4 FG Domains Could Form Dynamic Hydrogel Structures 000844435 5058_ $$a3.2.3 Mapping Transport Routes Suggests the Presence of Defined Central Structures3.2.4 The Nucleoplasmic Face; 3.3 Conclusions; References; Chapter 4: Non-canonical Roles of Nuclear Pore Proteins; 4.1 Introduction: The Nuclear Pore; 4.2 Mitosis: Many Points of Intersection with Nup Function; 4.2.1 Nups and Chromosome Congression; 4.2.2 Nups and Mitotic Spindle Assembly; 4.2.3 Nups and Spindle Assembly Checkpoint Maintenance; 4.2.4 Mitotic Exit and Cytokinesis; 4.3 Regulation of Gene Expression: The Chromatin Landscape and Beyond; 4.4 DNA Damage: Emerging Roles for Nups 000844435 5058_ $$a4.4.1 Nucleoporins and DNA Repair in Yeast4.4.2 Nucleoporins and DNA Repair in Mammalian Cells; 4.5 Pore Proteins at Cilia: Defining Where, Why, and How; 4.6 The NPC as a Signaling and Tethering Platform; 4.7 Further Considerations and Conclusions; References; Chapter 5: On the Role of the Channel Nucleoporins in Nuclear Transport; 5.1 Overview; 5.2 The Channel Nups Are Essential for Significant Nuclear Transport Rates Through the NPC; 5.3 Structural Characterization of the Channel Nups; 5.3.1 X-Ray Structures of the Channel Nups and Implications for Nuclear Transport 000844435 506__ $$aAccess limited to authorized users. 000844435 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed August 2, 2018). 000844435 650_0 $$aCytoplasm. 000844435 650_0 $$aNucleoproteins. 000844435 7001_ $$aYang, Weidong,$$eeditor. 000844435 77608 $$iPrint version: $$z3319773089$$z9783319773087$$w(OCoLC)1022773175 000844435 830_0 $$aNucleic acids and molecular biology ;$$vv. 33. 000844435 852__ $$bebk 000844435 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-77309-4$$zOnline Access$$91397441.1 000844435 909CO $$ooai:library.usi.edu:844435$$pGLOBAL_SET 000844435 980__ $$aEBOOK 000844435 980__ $$aBIB 000844435 982__ $$aEbook 000844435 983__ $$aOnline 000844435 994__ $$a92$$bISE