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Intro; Preface; References; Contents; Drug Discrimination: Historical Origins, Important Concepts, and Principles; 1 Introduction; 2 Historical Origins; 2.1 State Dependent Learning; 2.2 Drug Discrimination; 2.3 Two-Lever Operant Drug Discrimination; 3 Important Concepts and Principles of the Drug Discrimination Paradigm; 3.1 A Method to Measure Subjective Effects; 3.2 Classification of Drugs; 3.3 Tolerance and Cross-Tolerance; 3.4 Stereospecificity of Discriminative Stimulus Effects; 3.5 Receptor Mechanisms and Discriminative Stimulus Effects; 3.6 Individual Differences Between Subjects
3.7 Drug Development4 Summary and Overview of This Volume; References; Discriminative Stimulus Effects of Psychostimulants; 1 Introduction; 2 Discriminative Stimulus Effects of Psychostimulant Drugs; 3 A Note on the Sex of Experimental Subjects; 4 Monoamine Transporter Blocker: Cocaine; 4.1 Dopamine; 4.2 Norepinephrine; 4.3 Serotonin; 4.4 Non-monoaminergic Receptors; 5 Monoamine Transporter Substrate/Releaser: MDMA; 5.1 Stimulant: Hallucinogen Continuum; 5.2 Stereoisomerism; 5.3 Pharmacokinetic Considerations; 5.4 Discriminative Stimulus Effects of MDMA
6 Monoamine Transporter Substrate/Releaser: d-Amphetamine and Methamphetamine6.1 d-Amphetamine: Prototypical DA Releaser; 6.2 Methamphetamine: Prototypical DA Releaser; 7 Conclusion; References; Discriminative Stimulus Properties of S(-)-Nicotine: ``A Drug for All Seasons;́́ 1 Introduction; 2 Drug Discrimination; 2.1 Why Use Drug Discrimination (DD) Procedures to Study S(-)-Nicotine?; 2.2 Rationale; 2.3 Methodology; 2.3.1 Initial Shaping of Behavior; 2.3.2 Training Under Both Drug and Non-drug Conditions; 2.3.3 Testing Procedures; 2.3.4 Challenge Experiments; 2.3.5 Stimulus Generalization
1.1.3 Serotonin1.2 Nonhuman Primates; 1.3 Humans; 1.4 Neuroanatomical Targets; 1.5 New Paradigm for Advancing Knowledge and Pharmacotherapeutic Development with Ethanol Discriminations; References; Discriminative Stimulus Effects of Abused Inhalants; 1 Introduction; 2 Unique Methodological Aspects of Inhalant Discrimination Studies; 3 Inhalants as Drug Discrimination Training Stimuli; 4 Pharmacological Characterization of Inhalant Discriminative Stimuli; 4.1 Stimulus Effects of Inhalants: GABAA Receptors; 4.2 Stimulus Effects of Inhalants: NMDA Receptors
3.7 Drug Development4 Summary and Overview of This Volume; References; Discriminative Stimulus Effects of Psychostimulants; 1 Introduction; 2 Discriminative Stimulus Effects of Psychostimulant Drugs; 3 A Note on the Sex of Experimental Subjects; 4 Monoamine Transporter Blocker: Cocaine; 4.1 Dopamine; 4.2 Norepinephrine; 4.3 Serotonin; 4.4 Non-monoaminergic Receptors; 5 Monoamine Transporter Substrate/Releaser: MDMA; 5.1 Stimulant: Hallucinogen Continuum; 5.2 Stereoisomerism; 5.3 Pharmacokinetic Considerations; 5.4 Discriminative Stimulus Effects of MDMA
6 Monoamine Transporter Substrate/Releaser: d-Amphetamine and Methamphetamine6.1 d-Amphetamine: Prototypical DA Releaser; 6.2 Methamphetamine: Prototypical DA Releaser; 7 Conclusion; References; Discriminative Stimulus Properties of S(-)-Nicotine: ``A Drug for All Seasons;́́ 1 Introduction; 2 Drug Discrimination; 2.1 Why Use Drug Discrimination (DD) Procedures to Study S(-)-Nicotine?; 2.2 Rationale; 2.3 Methodology; 2.3.1 Initial Shaping of Behavior; 2.3.2 Training Under Both Drug and Non-drug Conditions; 2.3.3 Testing Procedures; 2.3.4 Challenge Experiments; 2.3.5 Stimulus Generalization
1.1.3 Serotonin1.2 Nonhuman Primates; 1.3 Humans; 1.4 Neuroanatomical Targets; 1.5 New Paradigm for Advancing Knowledge and Pharmacotherapeutic Development with Ethanol Discriminations; References; Discriminative Stimulus Effects of Abused Inhalants; 1 Introduction; 2 Unique Methodological Aspects of Inhalant Discrimination Studies; 3 Inhalants as Drug Discrimination Training Stimuli; 4 Pharmacological Characterization of Inhalant Discriminative Stimuli; 4.1 Stimulus Effects of Inhalants: GABAA Receptors; 4.2 Stimulus Effects of Inhalants: NMDA Receptors