Linked e-resources
Details
Table of Contents
Intro; Contents; Preface; History of Polymeric Gene Delivery Systems; Abstract; 1 Introduction; 2 First-Generation Polycations: DNA Binding, Compaction, and Targeting; 3 Second-Generation Polycations: Proton Sponges or Endosomolytic Polymers; 4 Third-Generation Polycations: Biodegradable and Biocompatible; 5 Pharmaceutical Precise Polymers; 6 Polymer-Containing Nanocomposites; 7 Virus-Inspired Multifunctional Dynamic Polymers; 8 Conclusions and Perspectives; Acknowledgements; References; Polymer
Nucleic Acid Interactions; Abstract; 1 Introduction; 2 Structure of DNA and siRNA; 2.1 DNA
2.2 siRNA3 Theories of DNA Interacting with Polymers; 3.1 Electrostatic Interaction; 3.2 Hydrophobic Interaction; 3.3 Hydrogen Bonds; 4 DNA/siRNA
Linear Polymer Interactions; 4.1 DNA/siRNA Condensation via Electrostatic Interaction; 4.2 Optimization of Polymers by Hydrophobic Interactions; 4.3 Polyplex Dissociation; 5 DNA/siRNA
Dendrimer/Dendron Interactions; 5.1 Electrostatic Interaction with Different Dendrimer Sizes; 5.2 Hydrogen Bonds by Surface Modification; 5.3 Hydrophobic Modulation by Surface Modification; 5.4 Flexibility of Dendrimers; 6 Conclusion and perspectives
AcknowledgementsReferences; Polysaccharide-based Nanoparticles for Gene Delivery; Abstract; 1 Introduction; 1.1 Chitosan; 1.2 Alginate; 1.3 Dextran; 1.4 Hyaluronan; 1.5 Pullulan; 1.6 Other Polysaccharides; 2 DNA Delivery; 3 siRNA Delivery; 4 Conclusion; Acknowledgements; References; Peptide-Based and Polypeptide-Based Gene Delivery Systems; Abstract; 1 Introduction; 2 Preparation of Peptide-Based and Polypeptide-Based Gene Carriers; 2.1 Directly Obtained from the Organism; 2.2 Obtained by Genetic Engineering; 2.3 Artificial Peptides
3 Primary Types of Peptide-Based and Polypeptide-Based Delivery Systems3.1 Polypeptide Directly Conjugated to Genetic Material; 3.2 Peptide-Based or Polypeptide-Based Gene Carriers; 4 Application of Functional Peptides in Gene Therapy; 4.1 Targeted Peptides for Pathological Tissues or Cells; 4.2 Cell-Penetrating Peptides; 4.3 Peptides with Endosomal Escape Capacity; 4.4 Nuclear Localization Signal Peptides; 4.5 Peptide-Based Hydrogel for Local Release of Genes; 4.6 Environmentally Responsive Peptides; 4.7 Multifunctional Peptide-Based Gene Delivery Systems; 5 Conclusion and Outlook
AcknowlegementsReferences; Degradable Polyethylenimine-Based Gene Carriers for Cancer Therapy; Abstract; 1 Introduction; 2 Degradable PEI Derivatives; 2.1 Ester Bond; 2.2 Disulfide Bond; 2.3 Imine Bond; 2.4 Carbamate Bond; 2.5 Amide Bond; 2.6 Ketal Bond; 2.7 Others; 3 Major Cancers: Application of Degradable PEI-Based Gene Carriers; 3.1 Lung Cancer; 3.2 Prostate Cancer; 3.3 Liver Cancer; 3.4 Breast Cancer; 3.5 Ovarian Cancer; 3.6 Cervical Cancer; 3.7 Melanoma; 3.8 Colon Cancer; 3.9 Other Cancers (Lymphoma, Glioblastoma, and Neuroma); 4 Conclusion and Future Perspectives; Acknowledgements
Nucleic Acid Interactions; Abstract; 1 Introduction; 2 Structure of DNA and siRNA; 2.1 DNA
2.2 siRNA3 Theories of DNA Interacting with Polymers; 3.1 Electrostatic Interaction; 3.2 Hydrophobic Interaction; 3.3 Hydrogen Bonds; 4 DNA/siRNA
Linear Polymer Interactions; 4.1 DNA/siRNA Condensation via Electrostatic Interaction; 4.2 Optimization of Polymers by Hydrophobic Interactions; 4.3 Polyplex Dissociation; 5 DNA/siRNA
Dendrimer/Dendron Interactions; 5.1 Electrostatic Interaction with Different Dendrimer Sizes; 5.2 Hydrogen Bonds by Surface Modification; 5.3 Hydrophobic Modulation by Surface Modification; 5.4 Flexibility of Dendrimers; 6 Conclusion and perspectives
AcknowledgementsReferences; Polysaccharide-based Nanoparticles for Gene Delivery; Abstract; 1 Introduction; 1.1 Chitosan; 1.2 Alginate; 1.3 Dextran; 1.4 Hyaluronan; 1.5 Pullulan; 1.6 Other Polysaccharides; 2 DNA Delivery; 3 siRNA Delivery; 4 Conclusion; Acknowledgements; References; Peptide-Based and Polypeptide-Based Gene Delivery Systems; Abstract; 1 Introduction; 2 Preparation of Peptide-Based and Polypeptide-Based Gene Carriers; 2.1 Directly Obtained from the Organism; 2.2 Obtained by Genetic Engineering; 2.3 Artificial Peptides
3 Primary Types of Peptide-Based and Polypeptide-Based Delivery Systems3.1 Polypeptide Directly Conjugated to Genetic Material; 3.2 Peptide-Based or Polypeptide-Based Gene Carriers; 4 Application of Functional Peptides in Gene Therapy; 4.1 Targeted Peptides for Pathological Tissues or Cells; 4.2 Cell-Penetrating Peptides; 4.3 Peptides with Endosomal Escape Capacity; 4.4 Nuclear Localization Signal Peptides; 4.5 Peptide-Based Hydrogel for Local Release of Genes; 4.6 Environmentally Responsive Peptides; 4.7 Multifunctional Peptide-Based Gene Delivery Systems; 5 Conclusion and Outlook
AcknowlegementsReferences; Degradable Polyethylenimine-Based Gene Carriers for Cancer Therapy; Abstract; 1 Introduction; 2 Degradable PEI Derivatives; 2.1 Ester Bond; 2.2 Disulfide Bond; 2.3 Imine Bond; 2.4 Carbamate Bond; 2.5 Amide Bond; 2.6 Ketal Bond; 2.7 Others; 3 Major Cancers: Application of Degradable PEI-Based Gene Carriers; 3.1 Lung Cancer; 3.2 Prostate Cancer; 3.3 Liver Cancer; 3.4 Breast Cancer; 3.5 Ovarian Cancer; 3.6 Cervical Cancer; 3.7 Melanoma; 3.8 Colon Cancer; 3.9 Other Cancers (Lymphoma, Glioblastoma, and Neuroma); 4 Conclusion and Future Perspectives; Acknowledgements