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000850658 019__ $$a1053783033
000850658 020__ $$a9783319778662$$q(electronic book)
000850658 020__ $$a3319778668$$q(electronic book)
000850658 020__ $$z9783319778655
000850658 020__ $$z331977865X
000850658 035__ $$aSP(OCoLC)on1112838008
000850658 035__ $$aSP(OCoLC)1112838008
000850658 040__ $$aYDX$$beng$$cYDX$$dN$T$$dGW5XE$$dN$T$$dEBLCP$$dOCLCF
000850658 049__ $$aISEA
000850658 050_4 $$aRS201.P65
000850658 08204 $$a615/.6$$223
000850658 24500 $$aPolymeric gene delivery systems$$h[electronic resource] /$$cYiyun Cheng, editor ; with contributions from Narsireddy Amreddy [and more].
000850658 260__ $$aCham :$$bSpringer,$$c2018.
000850658 300__ $$a1 online resource
000850658 336__ $$atext$$btxt$$2rdacontent
000850658 337__ $$acomputer$$bc$$2rdamedia
000850658 338__ $$aonline resource$$bcr$$2rdacarrier
000850658 4901_ $$aTopics in current chemistry collections,$$x2367-4067
000850658 5050_ $$aIntro; Contents; Preface; History of Polymeric Gene Delivery Systems; Abstract; 1 Introduction; 2 First-Generation Polycations: DNA Binding, Compaction, and Targeting; 3 Second-Generation Polycations: Proton Sponges or Endosomolytic Polymers; 4 Third-Generation Polycations: Biodegradable and Biocompatible; 5 Pharmaceutical Precise Polymers; 6 Polymer-Containing Nanocomposites; 7 Virus-Inspired Multifunctional Dynamic Polymers; 8 Conclusions and Perspectives; Acknowledgements; References; Polymer -- Nucleic Acid Interactions; Abstract; 1 Introduction; 2 Structure of DNA and siRNA; 2.1 DNA
000850658 5058_ $$a2.2 siRNA3 Theories of DNA Interacting with Polymers; 3.1 Electrostatic Interaction; 3.2 Hydrophobic Interaction; 3.3 Hydrogen Bonds; 4 DNA/siRNA -- Linear Polymer Interactions; 4.1 DNA/siRNA Condensation via Electrostatic Interaction; 4.2 Optimization of Polymers by Hydrophobic Interactions; 4.3 Polyplex Dissociation; 5 DNA/siRNA -- Dendrimer/Dendron Interactions; 5.1 Electrostatic Interaction with Different Dendrimer Sizes; 5.2 Hydrogen Bonds by Surface Modification; 5.3 Hydrophobic Modulation by Surface Modification; 5.4 Flexibility of Dendrimers; 6 Conclusion and perspectives
000850658 5058_ $$aAcknowledgementsReferences; Polysaccharide-based Nanoparticles for Gene Delivery; Abstract; 1 Introduction; 1.1 Chitosan; 1.2 Alginate; 1.3 Dextran; 1.4 Hyaluronan; 1.5 Pullulan; 1.6 Other Polysaccharides; 2 DNA Delivery; 3 siRNA Delivery; 4 Conclusion; Acknowledgements; References; Peptide-Based and Polypeptide-Based Gene Delivery Systems; Abstract; 1 Introduction; 2 Preparation of Peptide-Based and Polypeptide-Based Gene Carriers; 2.1 Directly Obtained from the Organism; 2.2 Obtained by Genetic Engineering; 2.3 Artificial Peptides
000850658 5058_ $$a3 Primary Types of Peptide-Based and Polypeptide-Based Delivery Systems3.1 Polypeptide Directly Conjugated to Genetic Material; 3.2 Peptide-Based or Polypeptide-Based Gene Carriers; 4 Application of Functional Peptides in Gene Therapy; 4.1 Targeted Peptides for Pathological Tissues or Cells; 4.2 Cell-Penetrating Peptides; 4.3 Peptides with Endosomal Escape Capacity; 4.4 Nuclear Localization Signal Peptides; 4.5 Peptide-Based Hydrogel for Local Release of Genes; 4.6 Environmentally Responsive Peptides; 4.7 Multifunctional Peptide-Based Gene Delivery Systems; 5 Conclusion and Outlook
000850658 5058_ $$aAcknowlegementsReferences; Degradable Polyethylenimine-Based Gene Carriers for Cancer Therapy; Abstract; 1 Introduction; 2 Degradable PEI Derivatives; 2.1 Ester Bond; 2.2 Disulfide Bond; 2.3 Imine Bond; 2.4 Carbamate Bond; 2.5 Amide Bond; 2.6 Ketal Bond; 2.7 Others; 3 Major Cancers: Application of Degradable PEI-Based Gene Carriers; 3.1 Lung Cancer; 3.2 Prostate Cancer; 3.3 Liver Cancer; 3.4 Breast Cancer; 3.5 Ovarian Cancer; 3.6 Cervical Cancer; 3.7 Melanoma; 3.8 Colon Cancer; 3.9 Other Cancers (Lymphoma, Glioblastoma, and Neuroma); 4 Conclusion and Future Perspectives; Acknowledgements
000850658 506__ $$aAccess limited to authorized users.
000850658 588__ $$aDescription based on print version record.
000850658 650_0 $$aPolymeric drug delivery systems.
000850658 650_0 $$aGene therapy.
000850658 7001_ $$aCheng, Yiyun.
000850658 77608 $$iPrint version:$$z331977865X$$z9783319778655$$w(OCoLC)1023525708
000850658 830_0 $$aTopics in current chemistry collections.
000850658 852__ $$bebk
000850658 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-77866-2$$zOnline Access$$91397441.1
000850658 909CO $$ooai:library.usi.edu:850658$$pGLOBAL_SET
000850658 980__ $$aEBOOK
000850658 980__ $$aBIB
000850658 982__ $$aEbook
000850658 983__ $$aOnline
000850658 994__ $$a92$$bISE