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000856081 019__ $$a1019612259$$a1021193654$$a1027045990$$a1048178653$$a1058538124$$a1066467287$$a1066595491$$a1079836306
000856081 020__ $$a9783319685823$$q(electronic book)
000856081 020__ $$a3319685821$$q(electronic book)
000856081 020__ $$z9783319685816
000856081 020__ $$z3319685813
000856081 0247_ $$a10.1007/978-3-319-68582-3$$2doi
000856081 035__ $$aSP(OCoLC)on1018942330
000856081 035__ $$aSP(OCoLC)1018942330$$z(OCoLC)1019612259$$z(OCoLC)1021193654$$z(OCoLC)1027045990$$z(OCoLC)1048178653$$z(OCoLC)1058538124$$z(OCoLC)1066467287$$z(OCoLC)1066595491$$z(OCoLC)1079836306
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000856081 049__ $$aISEA
000856081 050_4 $$aRD651
000856081 08204 $$a616.994$$223
000856081 1001_ $$aSarioglu, Sulen,$$eauthor.
000856081 24510 $$aTumor deposits :$$bmechanism, morphology and prognostic implications /$$cSulen Sarioglu.
000856081 264_1 $$aCham :$$bSpringer,$$c[2018]
000856081 264_4 $$c©2018
000856081 300__ $$a1 online resource
000856081 336__ $$atext$$btxt$$2rdacontent
000856081 337__ $$acomputer$$bc$$2rdamedia
000856081 338__ $$aonline resource$$bcr$$2rdacarrier
000856081 347__ $$atext file$$bPDF$$2rda
000856081 504__ $$aIncludes bibliographical references and index.
000856081 5050_ $$aIntro; Preface; Acknowledgment; Contents; 1: Mechanisms of Metastasis; Normal Tissue Versus Malignant Neoplasia; Molecular and Genetic Features; Genomic Instability; Metabolic Alterations; Limitless Replicative Potential; Angiogenesis, Vasculogenesis, Vascular Co-option, Lymphangiogenesis, and Neoneurogenesis; Autophagy; Apoptosis, Necroptosis, and Anoikis; Apoptosis; Anoikis; Necroptosis; Proteases: Degradation of the Extratumoral Spaces; Epithelial-Mesenchymal Transition; EMT Regulation; Mesenchymal-Epithelial Transition; EMT, Stem Cells, and Tumor-Initiating Cells; Cell Adhesion.
000856081 5058_ $$aTumor-Stroma InteractionsEscape from Immune Surveillance; Metastasis; Tumor Migration; Circulating Tumor Cells; Metastasis Suppressor Genes; Exosomes in Cancer Metastasis; Invasion of the Vessels; Extravasation; Metastatic Colonization, Tumor Dormancy, and Reactivation; Last Words; References; 2: Tumor Deposits; Mechanisms, Morphology, and Differential Diagnosis; Morphology and Differential Diagnosis of Free Tumor Deposits; Clinical Relevance of Free Tumor Deposits; Mechanisms of Tumor Deposit Formation.
000856081 5058_ $$aNeurotrophic Extravascular Migratory Metastasis, Perineural Invasion, and Perineural-Type Tumor Deposit FormationAngiotrophic Extravascular Migratory Metastasis and Perivascular-Type Tumor Deposit Formation; Tumor Deposits Associated with Lymphatics; Other Routes of Tumor Spread; References; 3: Tumor Deposits in Colorectal Cancer; Prognostic Factors in Colorectal Carcinomas; Proposed Mechanisms and Morphology of TDs in Colorectal Carcinomas; Classifications of TDs in Colorectal Carcinomas; Prognostic Studies on Tumor Deposits in Colorectal Carcinomas.
000856081 5058_ $$aDiscussion About TDs in Colorectal CarcinomasNeoadjuvant Radiotherapy and Tumor Deposits; References; 4: Tumor Deposits in Gastric Cancer; Morphologic and Molecular Classifications of the Gastric Carcinomas and Prognostic Features; EBV-Associated DNA Hypermethylation; Microsatellite Instability; Genomically Stable Tumors; Chromosomally Unstable Tumors; Prognostic Factors in Gastric Carcinomas; HER2: A Predictive Biomarker in Gastric Carcinoma; Trastuzumab for Gastric Cancer (ToGA Trial) (Bang YJ 2010); Methods for Evaluation of HER2 Amplification; Immunohistochemistry.
000856081 5058_ $$aIn Situ HybridizationThe Diagnostic Combination of IHC and ISH for HER2 Amplification; The Incidence of HER2 Amplification in Gastric and Gastroesophageal Carcinoma Cases; Implications for Treatment; Proposed Mechanisms and Morphology of Tumor Deposits in Gastric Carcinomas; Classifications of Tumor Deposits in Gastric Carcinomas; Prognostic Studies on Tumor Deposits in Gastric Carcinomas; Discussion About TDs in Gastric Carcinomas; References; 5: Tumor Deposits in Esophageal Carcinomas; Morphologic and Molecular Classifications of the Esophageal Carcinomas.
000856081 506__ $$aAccess limited to authorized users.
000856081 520__ $$aThis book presents the morphology, possible mechanisms of formation, and clinical relevance of tumor deposits (TDs) in different organs and parts of the body. It also describes the diagnostic features that are currently available for TDs and discusses the prognostic impact of TDs. The poor prognostic and predictive values of TDs were found to be as strong as distant metastasis in different series. TDs, best characterized by colorectal cancer, are irregular discrete tumor masses that are discontinuous from the leading edge of the tumor. However, even in colorectal cancers, the place of TDs in tumor staging (tumor, lymph node and distant metastasis categories) remains controversial. This book presents the possible mechanisms of TD formation, including neurotrophic and angiotrophic extravascular migratory metastasis, in comparison with the well-known mechanisms of metastasis. It also shows that TDs were identified in esophageal, gastric, salivary gland, head and neck, and breast carcinomas. The possible mechanisms leading to the frequent association of TDs and peritoneal carcinomatosis are discussed. This is a valuable resource for pathologists, oncologists, and surgeons who are looking for detailed information on the latest scientific insights into the pathology and prognostic implications of TDs.
000856081 588__ $$aOnline resource; title from PDF title page (viewed January 15, 2018).
000856081 650_0 $$aTumors.
000856081 650_0 $$aPathology, Surgical.
000856081 77608 $$iPrint version:$$aSarioglu, Sulen.$$tTumor deposits.$$dCham : Springer, [2018]$$z3319685813$$z9783319685816$$w(OCoLC)1002288433
000856081 852__ $$bebk
000856081 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-68582-3$$zOnline Access$$91397441.1
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000856081 980__ $$aEBOOK
000856081 980__ $$aBIB
000856081 982__ $$aEbook
000856081 983__ $$aOnline
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