Management of infections in the immunocompromised host / Brahm H. Segal, editor.
Segal, Brahm H., editor.
2018
RC582
Available Online

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Title Management of infections in the immunocompromised host / Brahm H. Segal, editor.
ISBN 9783319776743 (electronic book)
3319776746 (electronic book)
9783319776729
331977672X
DOI https://doi.org/10.1007/978-3-319-77674-3
Published Cham : Springer, [2018]
Copyright ©2018
Language English
Description 1 online resource : illustrations
Other Standard Identifiers 10.1007/978-3-319-77674-3 doi
Call Number RC582
Dewey Decimal Classification 616.07/9
Summary This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research. This book begins with an overview of the normally functioning immune system followed by a detailed discussion of the major primary immunodeficiencies. Specific chapters are dedicated to providing practical knowledge in the prevention and treatment of infections in specific immunocompromised patients, including those with cancer, transplant recipients, HIV infection, and autoimmune disorders. Emphasis is placed on diagnostic evaluation, antimicrobial selection that includes consideration of the threat of antimicrobial-resistant pathogens, and immunotherapy tailored to specific patients. Finally, dedicated chapters on stem cell transplantation for patients with primary immunodeficiencies, adoptive cellular immunotherapy, and gene therapy will provide readers with insight into these rapidly evolving and cutting edge therapies. Management of Infections in the Immunocompromised Host is a valuable resource for infectious diseases specialists, immunologists, oncologists, hematologists, general physicians, students, researchers, and all other working with immunocompromised patients.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Online resource; title from PDF title page (viewed June 25, 2018).
Added Author Segal, Brahm H., editor.
Available in Other Form Management of infections in the immunocompromised host.
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Intro; Dedication; Preface; Contents; Contributors; 1: Phagocytes; Origin and Development of Phagocytes; Mononuclear Phagocytes; Granulocytes; Recruitment, Chemotaxis, and Priming; Rolling; Priming; Adhesion; Transendothelial Cell Migration; Phagocytosis and Microbicidal Activity; Phagocytosis; Maturation of Phagosomes; Production of Reactive Oxygen Species; Production of Reactive Nitrogen Species; Oxygen-Independent Antimicrobial Systems; Extracellular Traps (ETs); Antigen Presentation; Concluding Comments; References; 2: T Cell Immunity; Introduction; Origin and Development of T Cells.

Immunodeficiency in the Absence of B CellsSummary; References; 4: Complement; The Complement System; Historical Aspects; Evolution of the Complement System; Synthesis, Distribution, and Catabolism of Complement; Activation of Complement; The Classical Pathway; The Lectin Pathway; The Alternative Pathway; C3: The Central Component of Complement; Activation of the Alternative Pathway; The "Tickover" Model; The Properdin-Directed Model; The Terminal Complement Pathway: Assembly of the Membrane Attack Complex; The Intracellular Complement System; Inhibition of Complement Activation.

Fluid-Phase Complement InhibitorsC1 Inhibitor (C1-INH); Factor I; C4b-Binding Protein (C4BP); Factor H (FH) and the FH Family of Proteins; Vitronectin (Vn); Clusterin (Cn); Membrane-Associated Complement Inhibitors; Complement Receptor 1 (CR1; Also Called CD35 or the Immune Adherence Receptor); CD46 (Membrane Cofactor Protein or MCP); CD55 (Decay-Accelerating Factor [DAF]); CD59 (Homologous Restriction Factor 20 (HRF-20), Membrane Attack Complex Inhibitory Factor (MACIF), or Protectin); Complement Receptor of the Immunoglobulin Superfamily (CRIg); Complement Receptors.

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