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000856174 019__ $$a1043603792$$a1043686702$$a1047677637
000856174 020__ $$a9783319906959$$q(electronic book)
000856174 020__ $$a331990695X$$q(electronic book)
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000856174 0247_ $$a10.1007/978-3-319-90695-9$$2doi
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000856174 035__ $$aSP(OCoLC)1043426658$$z(OCoLC)1043603792$$z(OCoLC)1043686702$$z(OCoLC)1047677637
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000856174 049__ $$aISEA
000856174 050_4 $$aQH588.S83$$bS74 2018
000856174 08204 $$a616.02/774$$223
000856174 24500 $$aStem cell genetics for biomedical research :$$bpast, present, and future /$$cRaul Delgado-Morales, editor.
000856174 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2018]
000856174 300__ $$a1 online resource (xi, 426 pages)
000856174 336__ $$atext$$btxt$$2rdacontent
000856174 337__ $$acomputer$$bc$$2rdamedia
000856174 338__ $$aonline resource$$bcr$$2rdacarrier
000856174 347__ $$atext file$$bPDF$$2rda
000856174 504__ $$aIncludes bibliographical references and index.
000856174 506__ $$aAccess limited to authorized users.
000856174 520__ $$aThis book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer's disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.
000856174 588__ $$aOnline resource; title from digital title page (viewed on July 27, 2018).
000856174 650_0 $$aStem cells$$xResearch.
000856174 650_0 $$aHuman genetics.
000856174 650_0 $$aMedicine$$xResearch.
000856174 7001_ $$aDelgado-Morales, Raul,$$eeditor.
000856174 77608 $$iPrint version:$$z3319906941$$z9783319906942$$w(OCoLC)1030591830
000856174 852__ $$bebk
000856174 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-90695-9$$zOnline Access$$91397441.1
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000856174 980__ $$aEBOOK
000856174 980__ $$aBIB
000856174 982__ $$aEbook
000856174 983__ $$aOnline
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