Acute neuronal injury : the role of excitotoxic programmed cell death mechanisms / Denson G. Fujikawa, editor.
2018
RC347
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Details
Title
Acute neuronal injury : the role of excitotoxic programmed cell death mechanisms / Denson G. Fujikawa, editor.
Edition
Second edition.
ISBN
9783319774954 (electronic book)
3319774956 (electronic book)
9783319774947
3319774948
3319774956 (electronic book)
9783319774947
3319774948
Published
Cham, Switzerland : Springer, [2018].
Copyright
©2018
Language
English
Description
1 online resource : illustrations.
Item Number
10.1007/978-3-319-77495-4 doi
Call Number
RC347
Dewey Decimal Classification
616.807
Summary
This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Vendor-supplied metadata.
Added Author
Fujikawa, Denson G., editor.
Available in Other Form
Print version: 9783319774947
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