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Intro; Preface; Acknowledgments and Reminiscences; Advances in Comparative Immunology Introduction; Why Study Comparative Immunology?; 2018: Evaluating the Impact of Comparative Immunology; Distinct Periods in Conceptualizing Comparative Immunology; Retrospective Look at Comparative Immunology; Egyptians' Discovery of Inflammation in Ancient Humans; Advent of the Modern Era: Élie Metchnikoff; Leo Loeb: The Biological Basis of Individuality
Emergence of Self/Nonself; 1960-1980; 1980-Present; What Hath Comparative Immunology Wrought?; Additional Reading List; Pre-1890 Phenomena.
1890s to 1950s1960s & 1970s; 1980s; 1990s; 2000s; Contents; Contributors; Part I: From Prokaryotes to Urochordates; Evolution of Immunity; History; The Pillars of Immunity; Processes; Evolutionary Lineages in a Diversity of Functions; Recognition of Self/Non-self; Immunological Memory; Cell-to-Cell Signaling; Pathogen Recognition Receptors; Immunoglobulins as Humoral Effector Mechanisms; Complement Factors as Humoral Effector Mechanisms; Lectins, Fibrinogen-Related Peptides, and Antimicrobial Peptides as Humoral Effector Mechanisms; Other Humoral Effector Mechanisms.
Cellular Effector MechanismsDiversity of Immune Reactions; Applied Aspects of Immune System Evolution; References; Allorecognition and Innate Immunity in the Dictyostelid Social Amoebae; Introduction; Phylogeny of Multicellular Eukaryotes; Homology or Convergent "Assembly of Parts" From an Ancestral Proteome; Allorecognition and the Stabilization of Cell Cooperation; Amoebae Versus Bacteria; Amoebal Innate Immunity; The Microbiome of the Social Amoeba; Summary; References; Cnidaria: Anthozoans in the Hot Seat; Introduction; Anthozoan Innate Immunity; The Mucosal Epithelia.
Effector Responses: Activation and SignalingImmune Cells, Phagocytosis, and Wound Healing; The Melanin Synthesis Pathways; Coagulation; Antimicrobial Activity; Apoptosis; Reactive Species; Antioxidants; Heat Shock Proteins; Fluorescent Proteins; Ecological Immunity: Focus on Scleractinian Corals; Immunity, Climate Change, and Conservation of Scleractinian Corals; Conclusion; References; Platyhelminthes: Molecular Dissection of the Planarian Innate Immune System; Introduction; The Planarian Model System; The Mucous Barrier; Pattern Recognition Receptors; Phagocytic Cells; Complement.
The Planarian Microbiome Contributes to Innate ImmunityFinal Remarks; References; Nematoda: The Caenorhabditis elegans Model for Innate Immunity
Interactions Between Worms and Pathogens, and Their Responses to Immunogenic Damage; Introduction; Signaling Pathways in the Caenorhabditis elegans Innate Immune Response; The p38/PMK-1 Signaling Pathway; The ERK/MPK-1 Signaling Pathway; Insulin-Like Signaling (DAF-16 and DAF-2); The DBL-1 Signaling Pathway; The C. elegans Viral Defense Strategy; Neuronal Regulation of Immunity; The Interface Between Innate Immunity and DNA Damage; Missing Links.
Emergence of Self/Nonself; 1960-1980; 1980-Present; What Hath Comparative Immunology Wrought?; Additional Reading List; Pre-1890 Phenomena.
1890s to 1950s1960s & 1970s; 1980s; 1990s; 2000s; Contents; Contributors; Part I: From Prokaryotes to Urochordates; Evolution of Immunity; History; The Pillars of Immunity; Processes; Evolutionary Lineages in a Diversity of Functions; Recognition of Self/Non-self; Immunological Memory; Cell-to-Cell Signaling; Pathogen Recognition Receptors; Immunoglobulins as Humoral Effector Mechanisms; Complement Factors as Humoral Effector Mechanisms; Lectins, Fibrinogen-Related Peptides, and Antimicrobial Peptides as Humoral Effector Mechanisms; Other Humoral Effector Mechanisms.
Cellular Effector MechanismsDiversity of Immune Reactions; Applied Aspects of Immune System Evolution; References; Allorecognition and Innate Immunity in the Dictyostelid Social Amoebae; Introduction; Phylogeny of Multicellular Eukaryotes; Homology or Convergent "Assembly of Parts" From an Ancestral Proteome; Allorecognition and the Stabilization of Cell Cooperation; Amoebae Versus Bacteria; Amoebal Innate Immunity; The Microbiome of the Social Amoeba; Summary; References; Cnidaria: Anthozoans in the Hot Seat; Introduction; Anthozoan Innate Immunity; The Mucosal Epithelia.
Effector Responses: Activation and SignalingImmune Cells, Phagocytosis, and Wound Healing; The Melanin Synthesis Pathways; Coagulation; Antimicrobial Activity; Apoptosis; Reactive Species; Antioxidants; Heat Shock Proteins; Fluorescent Proteins; Ecological Immunity: Focus on Scleractinian Corals; Immunity, Climate Change, and Conservation of Scleractinian Corals; Conclusion; References; Platyhelminthes: Molecular Dissection of the Planarian Innate Immune System; Introduction; The Planarian Model System; The Mucous Barrier; Pattern Recognition Receptors; Phagocytic Cells; Complement.
The Planarian Microbiome Contributes to Innate ImmunityFinal Remarks; References; Nematoda: The Caenorhabditis elegans Model for Innate Immunity
Interactions Between Worms and Pathogens, and Their Responses to Immunogenic Damage; Introduction; Signaling Pathways in the Caenorhabditis elegans Innate Immune Response; The p38/PMK-1 Signaling Pathway; The ERK/MPK-1 Signaling Pathway; Insulin-Like Signaling (DAF-16 and DAF-2); The DBL-1 Signaling Pathway; The C. elegans Viral Defense Strategy; Neuronal Regulation of Immunity; The Interface Between Innate Immunity and DNA Damage; Missing Links.