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Table of Contents
Intro; Contents; Introduction; Part I: Review of Hemostasis; 1: Local Tissues in Hemostasis and Platelet Review; 1.1 Blood Vessels; 1.2 Endothelium; 1.3 Endothelial Inhibition of Thrombosis; 1.4 Endothelial Promotion of Thrombosis; 1.5 Local Tissues Upon Vessel Injury; 1.6 Platelet Review; 1.7 Platelet Anatomy; 1.8 The Platelet; 1.9 Platelets and Clotting; 1.10 Platelets in Physiologic Hemostasis; 1.11 Platelet Activation; 1.12 Platelet Adhesion; 1.13 Platelet Aggregation; 1.14 Platelet Quality: Secretion; 1.15 Platelets in Pathologic Hemostasis (Thrombotic Disease); References.
2: Coagulation Enzymes Review and Review of Hemostasis: Putting It All Together2.1 Coagulation Factors; 2.2 The Factors; 2.3 Summary of Factors; 2.4 Cofactors; 2.5 Factors Requiring Vitamin K for Synthesis; 2.6 Endogenous Antithrombotic Factors; 2.7 Antithrombin; 2.8 Tissue Factor Pathway Inhibitor; 2.9 Thrombomodulin and Protein C; 2.10 Fibrinolytic System; 2.11 Review of Hemostasis: Putting It All Together; 2.11.1 Biochemical Model; 2.11.1.1 The Extrinsic/Initiator/Tissue Factor Pathway; 2.11.1.2 The Intrinsic/Propagator Pathway; 2.11.1.3 Common Pathway.
2.11.2 Cell-Based Model of Hemostasis2.11.3 Thrombus; References; Part II: Pathophysiology and Pharmacotherapy of Hemostasis in Dentistry; 3: Review of von Willebrand Disease and Perioperative Management in Dentistry; 3.1 von Willebrand Disease; 3.2 von Willebrand Factor (vWF); 3.3 Classification of vWD; 3.4 Clinical Presentation; 3.5 Management of the Dental Patient with vWD; References; 4: Review of Hemophilia A and B and Perioperative Management in Dentistry; 4.1 Pathophysiology; 4.2 Laboratory Findings; 4.3 Inhibitors; 4.4 Clinical Features; 4.5 Medical Management.
4.6 Mild Hemophilia A4.7 Mild Hemophilia B; 4.8 Moderate/Severe Hemophilia A and B; 4.9 Fresh Frozen Plasma (FFP) and Cryoprecipitate; 4.10 Dental Management; References; 5: Review of Thrombocytopenia and Perioperative Management in Dentistry; 5.1 Definition of Thrombocytopenia; 5.2 Pathophysiology of Thrombocytopenia; 5.3 Decreased Production; 5.4 Sequestration; 5.5 Increased Destruction-Immune-Related; 5.6 Nonimmune Platelet Destruction; 5.7 Perioperative Management of Thrombocytopenia; 5.7.1 Detailed History; 5.7.2 Physical Exam; 5.7.3 Laboratory Testing.
5.8 Management of the Thrombocytopenic Patient5.9 Platelet Transfusion; 5.10 Additional Considerations in the Management of the Thrombocytopenic Dental Patient; 5.11 Summary; References; 6: Review of Liver Disease and Perioperative Management in Dentistry; 6.1 Liver Disease: A Brief Review of Types, Etiologies, Pathophysiology, Signs, and Symptoms; 6.2 Disturbances in Hemostasis Associated with Liver Disease; 6.3 Pretreatment Evaluation of the Liver Disease Patient: The History and Physical Examination, Blood and Other Testing.
2: Coagulation Enzymes Review and Review of Hemostasis: Putting It All Together2.1 Coagulation Factors; 2.2 The Factors; 2.3 Summary of Factors; 2.4 Cofactors; 2.5 Factors Requiring Vitamin K for Synthesis; 2.6 Endogenous Antithrombotic Factors; 2.7 Antithrombin; 2.8 Tissue Factor Pathway Inhibitor; 2.9 Thrombomodulin and Protein C; 2.10 Fibrinolytic System; 2.11 Review of Hemostasis: Putting It All Together; 2.11.1 Biochemical Model; 2.11.1.1 The Extrinsic/Initiator/Tissue Factor Pathway; 2.11.1.2 The Intrinsic/Propagator Pathway; 2.11.1.3 Common Pathway.
2.11.2 Cell-Based Model of Hemostasis2.11.3 Thrombus; References; Part II: Pathophysiology and Pharmacotherapy of Hemostasis in Dentistry; 3: Review of von Willebrand Disease and Perioperative Management in Dentistry; 3.1 von Willebrand Disease; 3.2 von Willebrand Factor (vWF); 3.3 Classification of vWD; 3.4 Clinical Presentation; 3.5 Management of the Dental Patient with vWD; References; 4: Review of Hemophilia A and B and Perioperative Management in Dentistry; 4.1 Pathophysiology; 4.2 Laboratory Findings; 4.3 Inhibitors; 4.4 Clinical Features; 4.5 Medical Management.
4.6 Mild Hemophilia A4.7 Mild Hemophilia B; 4.8 Moderate/Severe Hemophilia A and B; 4.9 Fresh Frozen Plasma (FFP) and Cryoprecipitate; 4.10 Dental Management; References; 5: Review of Thrombocytopenia and Perioperative Management in Dentistry; 5.1 Definition of Thrombocytopenia; 5.2 Pathophysiology of Thrombocytopenia; 5.3 Decreased Production; 5.4 Sequestration; 5.5 Increased Destruction-Immune-Related; 5.6 Nonimmune Platelet Destruction; 5.7 Perioperative Management of Thrombocytopenia; 5.7.1 Detailed History; 5.7.2 Physical Exam; 5.7.3 Laboratory Testing.
5.8 Management of the Thrombocytopenic Patient5.9 Platelet Transfusion; 5.10 Additional Considerations in the Management of the Thrombocytopenic Dental Patient; 5.11 Summary; References; 6: Review of Liver Disease and Perioperative Management in Dentistry; 6.1 Liver Disease: A Brief Review of Types, Etiologies, Pathophysiology, Signs, and Symptoms; 6.2 Disturbances in Hemostasis Associated with Liver Disease; 6.3 Pretreatment Evaluation of the Liver Disease Patient: The History and Physical Examination, Blood and Other Testing.