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000856260 24500 $$aStandards for ocular toxicology and inflammation /$$cBrian C. Gilger, Cynthia S. Cook, Michael H. Brown, editors.
000856260 264_1 $$aCham :$$bSpringer,$$c2018.
000856260 300__ $$a1 online resource
000856260 336__ $$atext$$btxt$$2rdacontent
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000856260 338__ $$aonline resource$$bcr$$2rdacarrier
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000856260 5050_ $$aIntro; Preface; Contents; Chapter 1: Standards for Conducting Ophthalmic Examinations in Laboratory Animals; Introduction; Routine Examination; Slit-Lamp Biomicroscopy; Indirect/Direct Ophthalmoscopy; Pretest Examination; Additional Ophthalmic Diagnostic Procedures; Tonometry; Pachymetry; Fluorescein Staining; Photographic Documentation; Fluorescein Angiography; Electroretinography/Visual Evoked Potential; Optical Coherence Tomography; Specular Microscopy; Conclusion; References; Chapter 2: Standard Operating Procedures for Common Laboratory Animal Ocular Procedures; Introduction.
000856260 5058_ $$aAqueocentesis/Intracameral InjectionIntravitreal Injection/Vitreocentesis; Mouse; Rat; Rabbit; Porcine/Canine; Nonhuman Primates; Subconjunctival Injection; Retrobulbar; Subretinal Injections; Rodents; Large Animals; Rabbit; Porcine/Canine; Nonhuman Primate; Globe/Tissue Dissection for Ocular Drug Analysis and Pharmacokinetics; Conclusions; References; Chapter 3: Harmonization of Lesion Nomenclature in Laboratory Animals; Introduction; Orbit and Globe; Eyelids, Adnexa, and Conjunctiva; Cornea and Sclera; Aqueous/Anterior Chamber; Iris and Ciliary Body; Lens; Vitreous Humor.
000856260 5058_ $$aRetina, Choroid, and Optic NerveNeuro-Ophthalmology; Conclusions; References; For Additional Information of the SEND and INHAND Initiatives, Please See These Additional Resources:; Chapter 4: Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals; Introduction; Rodents; CD-1 Mice; Sprague-Dawley Rat; CD Rats; Wistar Rats; Long-Evans Rats; Other Rodent Species; Guinea Pig; Hamster; Rabbits; Beagles; Laboratory Minipigs; Cynomolgus Monkeys; Conclusions; References; Chapter 5: Standardized Scoring of Ocular Findings in the Context of Drug and Device Development Programs.
000856260 5058_ $$aIntroduction and BackgroundScoring of the Anterior Segment; The Standardization of Uveitis Nomenclature (SUN) System; The McDonald-Shadduck and Hackett-McDonald Systems; The Semi-quantitative Preclinical Ocular Toxicology Scoring (SPOTS) System: Anterior Segment; Pupillary Light Reflex (PLR); Conjunctiva; Corneal Opacity and Fluorescein Staining; Corneal Vascularization; Aqueous (Anterior Chamber) Flare; Aqueous (Anterior Chamber) Cell; Iris Involvement; Anterior Vitreous Cell; Lens Opacity; The SPOTS -- Modified SUN System; Scoring of the Posterior Segment.
000856260 5058_ $$aThe National Eye Institute (NEI) Scoring System for Vitreous InflammationThe SPOTS Scoring System: Posterior Segment; Vitreous Haze; Degraded Fundus View; Retinal Perivascular Sheathing; Intravitreal Test Articles; Scoring System Modifications; Species-Specific Considerations for Ocular Scoring; Rodents (Mice and Rats); Rabbits; Dogs; Pigs; Nonhuman Primates; Conclusion; References; Index.
000856260 506__ $$aAccess limited to authorized users.
000856260 520__ $$aThis book is an international effort to standardize the language, terms, and methods used in ocular toxicology. With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. It is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.
000856260 588__ $$aOnline resource; title from PDF title page (viewed September 6, 2018).
000856260 650_0 $$aOcular toxicology$$vCongresses.
000856260 7001_ $$aGilger, Brian C.,$$eeditor.
000856260 7001_ $$aCook, Cynthia S.,$$eeditor.
000856260 7001_ $$aBrown, Michael H.,$$eeditor.
000856260 77608 $$iPrint version:$$tStandards for ocular toxicology and inflammation.$$dCham : Springer, 2018$$z3319783637$$z9783319783635$$w(OCoLC)1024218467
000856260 852__ $$bebk
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