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000856278 020__ $$a9783319934853$$q(electronic book)
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000856278 0247_ $$a10.1007/978-3-319-93485-3$$2doi
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000856278 08204 $$a612.8$$223
000856278 24500 $$aHuman neural stem cells :$$bfrom generation to differentiation and application /$$cLeonora Buzanska, editor.
000856278 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2018]
000856278 300__ $$a1 online resource.
000856278 336__ $$atext$$btxt$$2rdacontent
000856278 337__ $$acomputer$$bc$$2rdamedia
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000856278 4901_ $$aResults and problems in cell differentiation ;$$v66
000856278 504__ $$aIncludes bibliographical references.
000856278 5050_ $$aIntro; Contents; Part I: Derivation and/or Generation of Human Neural Stem Cells; Chapter 1: Derivation of Neural Stem Cells from the Developing and Adult Human Brain; 1.1 Foetal Neural Stem Cells (NSCs); 1.1.1 Mitogens Used for In Vitro Proliferation of hNSCs; 1.1.2 Longer-Term Growth of hNSCs; 1.1.3 Regional Differences; 1.2 Adult Neural Stem Cells; 1.3 Good Manufacturing Practice Production; 1.4 Conclusion; References; Chapter 2: Human Somatic Stem Cell Neural Differentiation Potential; 2.1 Afterbirth Somatic Tissues; 2.1.1 Placenta; 2.1.1.1 Maternal Decidua-Derived Cells
000856278 5058_ $$a2.1.1.2 Fetal Chorion-Derived Cells2.1.2 Amnion and Amniotic Fluid; 2.1.2.1 Amniotic Epithelial-Derived Cells; 2.1.2.2 Amnion Mesenchyme-Derived Cells; 2.1.2.3 Amniotic Fluid-Derived Cells; 2.1.3 The Umbilical Cord; 2.1.3.1 Human Umbilical Cord Blood (hUCB); 2.1.3.2 Human Umbilical Cord Tissue (Wharton Jelly); 2.2 Adult Somatic Tissues; 2.2.1 Blood; 2.2.1.1 Menstrual Blood; 2.2.1.2 Peripheral Blood; 2.2.2 Bone Marrow; 2.3 Direct Comparison of the Neural Differentiation Capabilities of the Perinatal and Adult Somatic Tissues; 2.4 Conclusions; References
000856278 5058_ $$aChapter 3: Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury3.1 Introduction; 3.1.1 iPS-NPs Derivation and Differentiation; 3.1.2 iPS-NPs in the Treatment of Injured CNS; 3.1.3 iPS-NPs in the Treatment of SCI; 3.1.4 iPS-NPs in the Treatment of Acute SCI; 3.1.5 iPS-NPs in the Treatment of Chronic SCI; 3.1.6 iPS-NPs in the Treatment of Stroke; 3.1.7 iPS-NPs and Their Translation to Clinical Medicine; 3.2 Conclusions; References; Chapter 4: Generation of Human Neural Stem Cells by Direct Phenotypic Conversion; 4.1 Introduction
000856278 5058_ $$a4.1.1 Neural Stem Cells4.1.2 Reprogramming Technology; 4.1.3 Purpose; 4.2 Generation of iNSC; 4.2.1 Generation of Genome-Integrated iNSC; 4.2.2 Generation of Genome Integration-Free iNSC; 4.2.3 Rationale of Direct Phenotypic Conversion; 4.3 Application Fields of iNSC; 4.3.1 Application Fields of Genome-Integrating iNSC; 4.3.2 Application Fields of Genome Integration-Free iNSC; 4.4 Pros and Cons of iNSC; 4.5 Conclusions and Future Perspectives; References; Part II: Differentiation and Underlying Mechanisms; Chapter 5: Epigenetic Regulation of Human Neural Stem Cell Differentiation
000856278 5058_ $$a5.1 Introduction5.2 Molecular Mechanisms of Epigenetics; 5.3 Epigenetic Mechanism Regulating Generation of NSCs from Pluripotent Stem Cells and Neuronal Differentiation of NSCs; 5.4 Epigenetic Mechanisms Regulating Astrocytic Differentiation of NSCs; 5.5 Epigenetic Mechanisms Regulating Oligodendrocytic Differentiation of NSCs; 5.6 Investigation of Neurological Disorders Using Patient-Derived iPSCs; 5.7 Concluding Remarks and Perspective; References; Chapter 6: Induced Pluripotent Stem Cells Reveal Common Neurodevelopmental Genome Deprograming in Schizophrenia
000856278 506__ $$aAccess limited to authorized users.
000856278 520__ $$aThis book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
000856278 588__ $$aOnline resource; title from PDF title page (viewed September 18, 2018).
000856278 650_0 $$aNeural stem cells.
000856278 7001_ $$aBuzanska, Leonora,$$eeditor.
000856278 77608 $$iPrint version: $$z3319934848$$z9783319934846$$w(OCoLC)1035509912
000856278 830_0 $$aResults and problems in cell differentiation ;$$v66.
000856278 852__ $$bebk
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