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Cancer RNome : nature & evolution / Mansi Arora, Deepak Kaul.

Arora, Mansi, author.; Kaul, Deepak, author.
2018
RC268.4
Available Online
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Title
Cancer RNome : nature & evolution / Mansi Arora, Deepak Kaul.
Author
Arora, Mansi, author.
ISBN
9789811315688 (electronic book)
981131568X (electronic book)
9789811315671
DOI
https://doi.org/10.1007/978-981-13-1568-8
Published
Singapore : Springer, 2018.
Language
English
Description
1 online resource (xii, 313 pages) : illustrations
Item Number
10.1007/978-981-13-1568-8 doi
Call Number
RC268.4
Dewey Decimal Classification
616.99/4042
Summary
In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.
Bibliography, etc. Note
Includes bibliographical references.
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Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed November 8, 2018).
Added Author
Kaul, Deepak, author.
Available in Other Form
Print version: 9789811315671
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1. Section 1. RNome: Evolution and nature
Chapter. 1.1. RNA world hypothesis
Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions
2. Section 2. Cellular RNome: Chromatin dynamics
Chapter. 2.1. Chromatin modifications & transcription
Chapter. 2.2. RNA modifications and epitranscriptomics
Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA
3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?)
Chapter. 3.1. Genome instability and mutation
Chapter. 3.2. Tumor-promoting inflammation
Chapter. 3.3. DNA methylation addiction
Chapter. 3.4. Oncoviruses
Chapter. 3.5. Sustained proliferative signaling
Chapter. 3.6. Evasion of growth suppressors
Chapter. 3.7. Replicative immortality
Chapter. 3.8. Resisting Cell death
Chapter. 3.9. Invasion and metastasis
Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth
Chapter. 3.12. Tumor Immune-evasion
Chapter. 3.13. Cancer stem cells and tumor cell plasticity
4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers
Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.

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