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000856397 019__ $$a1079792485
000856397 020__ $$a9783319996646$$q(electronic book)
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000856397 0247_ $$a10.1007/978-3-319-99664-6$$2doi
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000856397 050_4 $$aQR201.E82
000856397 08204 $$a579.3/42$$223
000856397 24500 $$aEscherichia coli, a versatile pathogen /$$cGad Frankel, Eliora Z. Ron, editors.
000856397 264_1 $$aCham, Switzerland :$$bSpringer,$$c2018.
000856397 300__ $$a1 online resource (vii, 242 pages) :$$billustrations
000856397 336__ $$atext$$btxt$$2rdacontent
000856397 337__ $$acomputer$$bc$$2rdamedia
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000856397 4901_ $$aCurrent topics in microbiology and immunology,$$x0070-217X ;$$vvolume 416
000856397 5050_ $$aIntro; Foreword; Contents; 104 Shigella and Enteroinvasive Escherichia Coli; Abstract; 1 Introduction; 2 Evolution of Enteroinvasive Pathovars of E. Coli; 3 Colonization of the Intestinal Lumen and Preparation of the Virulence Arsenal; 4 Subversion of Intestinal Epithelial Cells; 4.1 Diarrhea-Inducing Toxins; 4.2 Invasion to the Colonic Epithelium; 4.2.1 Attachment to ECs; 4.2.2 Engulfment by IECs; 4.3 Intracellular Movement, Autophagy Escape, and Dissemination; 4.4 Epithelial Integrity Preservation; 5 Subversion of the Immune System; 5.1 Manipulation of the Host Innate Immunity
000856397 5058_ $$a5.1.1 Non-specific Barrier Subversion5.1.2 Intestinal Epithelial Cell Subversion; 5.1.3 Phagocytic Cell Subversion; 5.2 Manipulation of the Host Adaptive Immunity; 6 Concluding Remarks; Acknowledgements; References; 105 Enteroaggregative Escherichia coli; Abstract; 1 Introduction; 2 Pathogenicity Mechanisms; 3 Interrelationships with Other E. Coli Pathotypes; 4 Methods for the Detection, Identification and Characterisation; 5 Clinical Symptoms and Burden of Disease; 6 The Zoonotic Potential of EAEC and Contamination of the Environment; 7 Foodborne Transmission; 8 Biofilm Formation
000856397 5058_ $$a9 Antimicrobial Resistance10 Whole-Genome Sequencing; 11 Summary; References; 116 The Type III Secretion System of Pathogenic Escherichia coli; Abstract; 1 Introduction; 2 Enteric E. coli and the LEE-Encoded T3SS; 3 Regulation of T3SS Expression; 4 Assembly of the T3SS; 5 Assembly of the Basal Body and Export Apparatus; 6 The C-Ring/Sorting Complex; 7 The ATPase Complex; 8 Inner Rod and Needle Assembly; 9 Filament and Translocon Assembly; 10 The Roles of Chaperones in T3SS Assembly and Secretion; 11 The ETT2: A Second T3SS?; 12 In Vitro and in Vivo Tools to Study the E. coli T3SS
000856397 506__ $$aAccess limited to authorized users.
000856397 520__ $$aEscherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
000856397 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 12, 2018).
000856397 650_0 $$aEscherichia coli.
000856397 7001_ $$aFrankel, Gad,$$eeditor.
000856397 7001_ $$aRon, Eliora Z.,$$eeditor.
000856397 77608 $$iPrint version: $$z9783319996639
000856397 77608 $$iPrint version: $$z9783319996653
000856397 830_0 $$aCurrent topics in microbiology and immunology ;$$v416.$$x0070-217X
000856397 852__ $$bebk
000856397 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-99664-6$$zOnline Access$$91397441.1
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000856397 980__ $$aBIB
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