Escherichia coli, a versatile pathogen / Gad Frankel, Eliora Z. Ron, editors.
Frankel, Gad, editor.; Ron, Eliora Z., editor.
2018
QR201.E82
Available Online

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Title Escherichia coli, a versatile pathogen / Gad Frankel, Eliora Z. Ron, editors.
ISBN 9783319996646 (electronic book)
3319996649 (electronic book)
9783319996639
DOI https://doi.org/10.1007/978-3-319-99664-6
Published Cham, Switzerland : Springer, 2018.
Language English
Description 1 online resource (vii, 242 pages) : illustrations
Item Number 10.1007/978-3-319-99664-6 doi
Call Number QR201.E82
Dewey Decimal Classification 579.3/42
Summary Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Online resource; title from PDF title page (SpringerLink, viewed November 12, 2018).
Added Author Frankel, Gad, editor.
Ron, Eliora Z., editor.
Series Current topics in microbiology and immunology ; 416. 0070-217X
Available in Other Form Print version: 9783319996639
Print version: 9783319996653
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Intro; Foreword; Contents; 104 Shigella and Enteroinvasive Escherichia Coli; Abstract; 1 Introduction; 2 Evolution of Enteroinvasive Pathovars of E. Coli; 3 Colonization of the Intestinal Lumen and Preparation of the Virulence Arsenal; 4 Subversion of Intestinal Epithelial Cells; 4.1 Diarrhea-Inducing Toxins; 4.2 Invasion to the Colonic Epithelium; 4.2.1 Attachment to ECs; 4.2.2 Engulfment by IECs; 4.3 Intracellular Movement, Autophagy Escape, and Dissemination; 4.4 Epithelial Integrity Preservation; 5 Subversion of the Immune System; 5.1 Manipulation of the Host Innate Immunity

5.1.1 Non-specific Barrier Subversion5.1.2 Intestinal Epithelial Cell Subversion; 5.1.3 Phagocytic Cell Subversion; 5.2 Manipulation of the Host Adaptive Immunity; 6 Concluding Remarks; Acknowledgements; References; 105 Enteroaggregative Escherichia coli; Abstract; 1 Introduction; 2 Pathogenicity Mechanisms; 3 Interrelationships with Other E. Coli Pathotypes; 4 Methods for the Detection, Identification and Characterisation; 5 Clinical Symptoms and Burden of Disease; 6 The Zoonotic Potential of EAEC and Contamination of the Environment; 7 Foodborne Transmission; 8 Biofilm Formation

9 Antimicrobial Resistance10 Whole-Genome Sequencing; 11 Summary; References; 116 The Type III Secretion System of Pathogenic Escherichia coli; Abstract; 1 Introduction; 2 Enteric E. coli and the LEE-Encoded T3SS; 3 Regulation of T3SS Expression; 4 Assembly of the T3SS; 5 Assembly of the Basal Body and Export Apparatus; 6 The C-Ring/Sorting Complex; 7 The ATPase Complex; 8 Inner Rod and Needle Assembly; 9 Filament and Translocon Assembly; 10 The Roles of Chaperones in T3SS Assembly and Secretion; 11 The ETT2: A Second T3SS?; 12 In Vitro and in Vivo Tools to Study the E. coli T3SS

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