Quantification of contrast kinetics in clinical imaging.
2018
RC78.7.C65
Available Online

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Title Quantification of contrast kinetics in clinical imaging.
ISBN 9783319646381 (electronic book)
3319646389 (electronic book)
3319646370
9783319646374
Publication Details [S.l.] : SPRINGER INTERNATIONAL PU, 2018.
Language English
Description 1 online resource
Item Number 10.1007/978-3-319-64638-1 doi
Call Number RC78.7.C65
Dewey Decimal Classification 616.07/54
Summary This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Available in Other Form Print version: 9783319646374
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Intro; Preface; Contents; Acronyms; 1 Introduction to Contrast-Enhanced Imaging; 1.1 Imaging Technology; 1.1.1 Magnetic Resonance Imaging; 1.1.2 Ultrasound Imaging; 1.1.3 X-ray Imaging and Computed Tomography; 1.1.4 Nuclear Scintigraphy; 1.2 Contrast Agents and Image Enhancement; References; 2 Introduction to Pharmacokinetic Modeling; 2.1 Indicator Dilution Theory; 2.2 Modeling of Contrast Kinetics; 2.3 Model Fitting and Regression Techniques; References; 3 Intravascular Contrast Agents; 3.1 Imaging and Calibration; 3.1.1 Ultrasound Contrast Agents; 3.1.2 Blood Pool MR Contrast Agents

3.2 Pharmacokinetic Modeling3.3 Clinical Applications; 3.3.1 Cardiology; 3.3.2 Oncology; References; 4 Extravascular Contrast Agents; 4.1 Imaging and Calibration; 4.1.1 Dynamic Contrast-Enhanced CT (DCE-CT); 4.1.2 Dynamic Contrast-Enhanced MRI (DCE-MRI); 4.2 Pharmacokinetic Modeling; 4.2.1 Compartmental (Lumped) Models; 4.2.2 Distributed Models; 4.2.3 Modeling of Vascular Transport; 4.3 Clinical Applications; 4.3.1 Cardiology; 4.3.2 Oncology; References; 5 Molecular Contrast Agents; 5.1 Imaging and Calibration; 5.1.1 PET and SPECT Radioactive Tracers; 5.1.2 US Molecular Contrast Agents

5.1.3 MR Molecular Contrast Agents5.1.4 CT Molecular Contrast Agents; 5.2 Pharmacokinetic Modeling; 5.2.1 PET and SPECT Radioactive Tracers; 5.2.2 US Molecular Contrast Agents; 5.2.3 MR Molecular Contrast Agents; 5.3 Clinical Applications; 5.3.1 Cardiology; 5.3.2 Oncology; References

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