000856541 000__ 04629cam\a2200517M\\4500 000856541 001__ 856541 000856541 005__ 20230306145142.0 000856541 006__ m\\\\\o\\d\\\\\\\\ 000856541 007__ cr\un\nnnunnun 000856541 008__ 181127s2018\\\\xx\\\\\\o\\\\\000\0\eng\d 000856541 019__ $$a1065523686$$a1079785714 000856541 020__ $$a9783319646381$$q(electronic book) 000856541 020__ $$a3319646389$$q(electronic book) 000856541 020__ $$z3319646370 000856541 020__ $$z9783319646374 000856541 0248_ $$a10.1007/978-3-319-64638-1$$2doi 000856541 035__ $$aSP(OCoLC)on1074393466 000856541 035__ $$aSP(OCoLC)1074393466$$z(OCoLC)1065523686$$z(OCoLC)1079785714 000856541 040__ $$aYDX$$beng$$cYDX$$dUKMGB$$dOCLCO$$dGW5XE$$dEBLCP$$dN$T$$dOCLCF$$dDKU 000856541 049__ $$aISEA 000856541 050_4 $$aRC78.7.C65 000856541 08204 $$a616.07/54$$223 000856541 24500 $$aQuantification of contrast kinetics in clinical imaging. 000856541 260__ $$a[S.l.] :$$bSPRINGER INTERNATIONAL PU,$$c2018. 000856541 300__ $$a1 online resource 000856541 336__ $$atext$$2rdacontent 000856541 337__ $$acomputer$$2rdamedia 000856541 338__ $$aonline resource$$2rdacarrier 000856541 347__ $$atext file$$bPDF$$2rda 000856541 504__ $$aIncludes bibliographical references. 000856541 5050_ $$aIntro; Preface; Contents; Acronyms; 1 Introduction to Contrast-Enhanced Imaging; 1.1 Imaging Technology; 1.1.1 Magnetic Resonance Imaging; 1.1.2 Ultrasound Imaging; 1.1.3 X-ray Imaging and Computed Tomography; 1.1.4 Nuclear Scintigraphy; 1.2 Contrast Agents and Image Enhancement; References; 2 Introduction to Pharmacokinetic Modeling; 2.1 Indicator Dilution Theory; 2.2 Modeling of Contrast Kinetics; 2.3 Model Fitting and Regression Techniques; References; 3 Intravascular Contrast Agents; 3.1 Imaging and Calibration; 3.1.1 Ultrasound Contrast Agents; 3.1.2 Blood Pool MR Contrast Agents 000856541 5058_ $$a3.2 Pharmacokinetic Modeling3.3 Clinical Applications; 3.3.1 Cardiology; 3.3.2 Oncology; References; 4 Extravascular Contrast Agents; 4.1 Imaging and Calibration; 4.1.1 Dynamic Contrast-Enhanced CT (DCE-CT); 4.1.2 Dynamic Contrast-Enhanced MRI (DCE-MRI); 4.2 Pharmacokinetic Modeling; 4.2.1 Compartmental (Lumped) Models; 4.2.2 Distributed Models; 4.2.3 Modeling of Vascular Transport; 4.3 Clinical Applications; 4.3.1 Cardiology; 4.3.2 Oncology; References; 5 Molecular Contrast Agents; 5.1 Imaging and Calibration; 5.1.1 PET and SPECT Radioactive Tracers; 5.1.2 US Molecular Contrast Agents 000856541 5058_ $$a5.1.3 MR Molecular Contrast Agents5.1.4 CT Molecular Contrast Agents; 5.2 Pharmacokinetic Modeling; 5.2.1 PET and SPECT Radioactive Tracers; 5.2.2 US Molecular Contrast Agents; 5.2.3 MR Molecular Contrast Agents; 5.3 Clinical Applications; 5.3.1 Cardiology; 5.3.2 Oncology; References 000856541 506__ $$aAccess limited to authorized users. 000856541 520__ $$aThis book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging. 000856541 650_0 $$aMedicine. 000856541 650_0 $$aContrast media (Diagnostic imaging) 000856541 650_0 $$aContrast-enhanced ultrasound. 000856541 650_0 $$aContrast-enhanced magnetic resonance imaging. 000856541 650_0 $$aMedical radiology. 000856541 650_0 $$aOncology. 000856541 77608 $$iPrint version: $$z3319646370$$z9783319646374$$w(OCoLC)992782108 000856541 852__ $$bebk 000856541 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-64638-1$$zOnline Access$$91397441.1 000856541 909CO $$ooai:library.usi.edu:856541$$pGLOBAL_SET 000856541 980__ $$aEBOOK 000856541 980__ $$aBIB 000856541 982__ $$aEbook 000856541 983__ $$aOnline 000856541 994__ $$a92$$bISE