@article{856606,
      recid = {856606},
      author = {Miele, Lucio, and Artavanis-Tsakonas, Spyros,},
      title = {Targeting Notch in cancer : from the fruit fly to the  Clinic /},
      pages = {1 online resource (viii, 389 pages).},
      abstract = {The serendipitously discovered link between developmental  biology and cancer, touched of an explosion of discoveries  on the role of Notch in human malignancies, including every  aspect of cancer biology, from control of differentiation,  proliferation and apoptosis in transformed cells to  angiogenesis, tumor-stroma interaction and anti-cancer  immune responses. A number of observations have revealed  that Notch even plays a role in the renewal of cancer stem  cells and tumor initiating cells, which are thought to be a  major cause of resistance to treatment. Targeting Notch in  Cancer will provide researchers, oncologists,  pharmacologists and students with a detailed understanding  of the intricate cross-talk between Notch and other  pathways of therapeutic interest so to better design  rational drug combinations for specific diseases and  disease subsets. Divided into two parts, Part I describes  in detail what we know about the genetics, molecular  biology, biochemistry and structural biology of Notch, as  well as the role of Notch in such processes as angiogenesis  and immune surveillance. Without insights gained from these  basic studies, rational targeting of Notch in human disease  would be impossible. Part II describes the role of Notch  and ongoing experimental therapeutic efforts in the most  important subtypes of human cancers, organized in a  clinically oriented fashion by organs and systems  affected.},
      url = {http://library.usi.edu/record/856606},
      doi = {https://doi.org/10.1007/978-1-4939-8859-4},
}