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Title
Targeting Notch in cancer : from the fruit fly to the Clinic / Lucio Miele, Spyros Artavanis-Tsakonas, editors.
ISBN
9781493988594 (electronic book)
149398859X (electronic book)
9781493988570
1493988573
Published
New York, NY : Springer, [2018]
Language
English
Description
1 online resource (viii, 389 pages).
Item Number
10.1007/978-1-4939-8859-4 doi
Call Number
RC262 .T37 2018
Dewey Decimal Classification
616.99/4
Summary
The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Description based on online resource; title from digital title page (viewed on December 28, 2018).
Available in Other Form
Print version: 9781493988570
Structural Biology of Notch Signaling
Non-Canonical Notch Signaling
Dual Function of Notch Signaling in Cancer - Oncogene and Tumorsuppressor
Out on the Fringe: Modulation of Notch Signaling by Glycosylation
Notch signaling: A pivot regulator of adaptive and innate immunity
Notch in Ovarian Cancer
Notch Signaling in Graft-versus-Host Disease
Notch Signaling in T-Cell Acute Lymphoblastic Leukemia and Other Hematologic Malignancies
The Role of Notch in Breast Cancer
Notch in Lung Cancer
Notch Signaling in Pediatric Soft tissue Sarcoma
Notch Ligands in Hematopoietic Stem Cell production
Notch Signaling in the normal intestine and intestinal Cancer
Notch Signaling in Estrogen-Dependent Cancers
Index.
