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Intro; Preface; Contents; 1: Epidemiology and Comorbidities; 1.1 Introduction and Epidemiology; 1.2 Definition and Classification; 1.3 Pathogenesis of Comorbidities; 1.3.1 Hormone-Like Adipokines; 1.3.2 Inflammatory Cytokines and Anti-inflammatory Factors; 1.4 Decreased Life Expectancy and Mortality; 1.4.1 Mortality: All-Cause and Disease-Specific Causes; 1.4.2 Population Attributable Fraction; 1.4.3 Current Developments; 1.5 Comorbidities in General; 1.6 Symptoms and Comorbidities More Specifically Related to the Gastrointestinal Tract

1.7 Symptoms Related to the Gastrointestinal Tract1.8 Comorbid Diseases Related to the Gastrointestinal Tract; 1.8.1 Oesophagus and Stomach; 1.8.1.1 Gastro-Oesophageal Reflux Disease; Putative Causative Mechanisms; Mechanical Mechanisms; Humoral Mechanisms; Role of General Adiposity and Visceral Adiposity; Meta-Analyses and Cohort Studies; What Is the Natural History of GORD?; 1.8.1.2 Barrett's Oesophagus; Case-Control Studies and BMI and Waist; Meta-Analyses; The Visceral Fat Pathway; Visceral Fat Measurements; Subcutaneous Fat Measurements; Metabolic Syndrome; Secreted Adipokines

LeptinAdiponectin; Both Leptin and Adiponectin; 1.8.1.3 Oesophageal Adenocarcinoma and Gastro-Oesophageal Junction/Gastric Cardia Adenocarcinoma; Meta-Analyses; Recent Cohort and Case-Control Studies; 1.8.1.4 Gastric Cancer; 1.8.1.5 Implications for Clinical Practice; 1.8.2 Gallbladder and Pancreas; 1.8.2.1 Gallbladder; Gallbladder Stones; Gallstones and Complications; Pathophysiology of Gallstone Formation in Obesity; 1.8.2.2 Pancreas; Acute Pancreatitis; Meta-Analyses; Why Are the Obese at Risk of Acute Pancreatitis and Local and Systemic Complications?; Pancreatic Cancer

1.8.2.3 Implications for Clinical Practice1.8.3 Rectocolon; 1.8.3.1 Colorectal Adenoma; Meta-Analyses; 1.8.3.2 Colorectal Carcinoma; Meta-Analyses; 1.8.3.3 Pathophysiology of Obesity in Relation to Adenoma and Carcinoma; Metabolic Syndrome; Visceral Fat and Adipokines; 1.8.3.4 Implications for Clinical Practice; 1.8.4 Liver; 1.8.4.1 Non-alcoholic Fatty Liver Disease; 1.8.4.2 Hepatocellular Carcinoma; Pathophysiology of Obesity in Relation to NAFLD; Pathophysiology of Obesity in Relation to Hepatocellular Carcinoma; 1.8.4.3 Implications for Clinical Practice

1.8.5 Gastrointestinal Cancers1.8.5.1 Cohort Studies; 1.8.5.2 Meta-Analyses; 1.8.5.3 Implications for Clinical Practice; References; 2: Current Endoscopic/Laparoscopic Bariatric Procedures; 2.1 Introduction; 2.2 Endoscopic Bariatric and Metabolic Therapies; 2.3 Gastric Endoscopic Bariatric and Metabolic Therapies; 2.3.1 Non-invasive Endoscopic Bariatric and Metabolic Therapies; 2.3.1.1 Intragastric Balloon Treatment; Single Ballloons; Orbera Balloon (Formerly Bioenterics Intragastric Balloon (BIB); Apollo Endosurgery, Austin, TX, USA); Efficacy and Safety; Predictors of Weight Loss

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