000856837 000__ 04720cam\a2200529Ii\4500 000856837 001__ 856837 000856837 005__ 20230306145155.0 000856837 006__ m\\\\\o\\d\\\\\\\\ 000856837 007__ cr\un\nnnunnun 000856837 008__ 181208s2018\\\\sz\\\\\\ob\\\\000\0\eng\d 000856837 019__ $$a1077496472$$a1078781312$$a1079828611 000856837 020__ $$a9783319987705$$q(electronic book) 000856837 020__ $$z9783319987699 000856837 020__ $$a3319987704 000856837 020__ $$z3319987690 000856837 0247_ $$a10.1007/978-3-319-98770-5$$2doi 000856837 035__ $$aSP(OCoLC)on1078550524 000856837 035__ $$aSP(OCoLC)1078550524$$z(OCoLC)1077496472$$z(OCoLC)1078781312$$z(OCoLC)1079828611 000856837 040__ $$aEBLCP$$beng$$erda$$cEBLCP$$dGW5XE$$dDKU$$dYDX$$dUAB$$dN$T 000856837 049__ $$aISEA 000856837 050_4 $$aRC136.8 000856837 08204 $$a616.9/112$$223 000856837 24500 $$aCongenital cytomegalovirus infection :$$bepidemiology, diagnosis, therapy /$$cGabriele Halwachs-Baumann, editor. 000856837 250__ $$aSecond edition. 000856837 264_1 $$aCham :$$bSpringer,$$c2018. 000856837 300__ $$a1 online resource (147 pages) 000856837 336__ $$atext$$btxt$$2rdacontent 000856837 337__ $$acomputer$$bc$$2rdamedia 000856837 338__ $$aonline resource$$bcr$$2rdacarrier 000856837 504__ $$aIncludes bibliographical references. 000856837 5050_ $$aIntro; Preface; Contents; 1: Long Known, Long Ignored: A Brief History of Cytomegalovirus Research; 1.1 Beginnings: 1881-1914; 1.2 Between the Wars: 1914-1930; 1.3 From 1930 to 1960; 1.4 From 1960 to the Present; References; 2: Virus-Host Interaction for Defense and Transmission; 2.1 The Virus; 2.2 The Host; 2.2.1 Cell Types Involved in Replication and Distribution; 2.2.2 The Immune System: Strengths and Weakness; 2.2.2.1 The Innate Immune System; 2.2.2.2 The Adaptive (Acquired) Immune System; 2.2.3 The Placenta: A Barrier? 000856837 5058_ $$a2.2.4 Cytomegalovirus-Placenta-Fetus: A Slippery Slope Between Defense and TransmissionReferences; 3: Epidemiology: The Influence of Socioeconomic Differences; 3.1 Infant Mortality as a Social Mirror; 3.2 One Effect: Many Causes; 3.2.1 Maternal Etiology; 3.2.2 Fetal Etiology; 3.2.3 Placental Etiology; 3.3 Epidemiology of Congenital CMV Infection; 3.3.1 Congenital CMV and Virus Strains; References; 4: Prospects and Obstacles of Diagnosis; 4.1 Screening for Congenital CMV Infection; 4.1.1 Screening of the Mother; 4.1.2 Screening of the Newborn; 4.2 Diagnosis of Congenital CMV Infection 000856837 5058_ $$a4.2.1 Prenatal Diagnosis4.2.2 Neonatal Diagnosis; References; 5: Clinical Outcome: Acute Symptoms and Sleeping Hazards; 5.1 Relevance of Connatal CMV Infection for the Pediatrician and Neonatologist; 5.2 The Tip of the Iceberg; 5.3 Lucky Chance by Neonatal Immune Response; 5.4 Features of Symptomatic CMV Infection; 5.5 Timing of Infection; 5.6 Symptoms of the Central Nervous System in Detail; 5.6.1 Microcephaly; 5.6.2 Ocular Defects; 5.6.3 Hearing Loss; 5.6.4 Mental and Psychomotor Retardation; 5.6.5 Seizures; 5.7 Unspecific Symptoms in Detail; 5.7.1 Temperature Instability 000856837 5058_ $$a5.7.2 Perfusion and Rash5.7.3 Lung; 5.7.4 Liver; 5.7.5 Jaundice; 5.7.6 Spleen; 5.7.7 Platelet System; 5.7.8 Anemia; 5.7.9 Gastrointestinal Tract; 5.8 Asymptomatic Infection; 5.9 Differential Diagnosis; References; 6: Prevention and Therapy: More than Trial and Error; 6.1 Antivirals; 6.1.1 Treatment of Pregnant Women; 6.1.2 Treatment of Neonates; 6.2 Passive Immunization; 6.3 Active Immunization (Vaccination); References; 7: How to Save Money: Congenital CMV Infection and the Economy; 7.1 Introduction; 7.2 Methodology; 7.2.1 Incidence-Based Approach; 7.2.2 Cost Calculation 000856837 5058_ $$a7.2.3 Cost of Sequelae7.2.3.1 Direct Cost Data; 7.2.3.2 Indirect Cost Data; 7.3 Cost of Illness in Germany; 7.3.1 Total Societal Costs; 7.3.1.1 Direct Cost; 7.3.1.2 Indirect Costs; 7.3.2 Sensitivity Analysis; 7.3.3 Impact Through Prevention; 7.4 Discussion; Addendum; References 000856837 506__ $$aAccess limited to authorized users. 000856837 520__ $$aCongenital cytomegalovirus infection is the most common intrauterine transmitted viral infection. This book details the history of this disease, its pathophysiological background, epidemiology and symptoms as well as diagnostic and therapeutic strategies. 000856837 588__ $$aDescripition based on print version record. 000856837 650_0 $$aCytomegalovirus infections$$xEpidemiology. 000856837 650_0 $$aCytomegalovirus infections$$xDiagnosis. 000856837 650_0 $$aCytomegalovirus infections$$xTreatment. 000856837 7001_ $$aHalwachs-Baumann, Gabriele. 000856837 77608 $$iPrint version:$$aHalwachs-Baumann, Gabriele$$tCongenital Cytomegalovirus Infection : Epidemiology, Diagnosis, Therapy$$dCham : Springer,c2018$$z9783319987699 000856837 852__ $$bebk 000856837 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-98770-5$$zOnline Access$$91397441.1 000856837 909CO $$ooai:library.usi.edu:856837$$pGLOBAL_SET 000856837 980__ $$aEBOOK 000856837 980__ $$aBIB 000856837 982__ $$aEbook 000856837 983__ $$aOnline 000856837 994__ $$a92$$bISE