000866202 000__ 04677cam\a2200529Ii\4500 000866202 001__ 866202 000866202 005__ 20230306145815.0 000866202 006__ m\\\\\o\\d\\\\\\\\ 000866202 007__ cr\cn\nnnunnun 000866202 008__ 190319s2019\\\\si\\\\\\ob\\\\000\0\eng\d 000866202 019__ $$a1090281431$$a1090445592$$a1090542766 000866202 020__ $$a9789811358777$$q(electronic book) 000866202 020__ $$a981135877X$$q(electronic book) 000866202 020__ $$z9789811358760 000866202 020__ $$z9811358761 000866202 035__ $$aSP(OCoLC)on1090130143 000866202 035__ $$aSP(OCoLC)1090130143$$z(OCoLC)1090281431$$z(OCoLC)1090445592$$z(OCoLC)1090542766 000866202 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dYDX$$dEBLCP$$dGW5XE 000866202 049__ $$aISEA 000866202 050_4 $$aRB43.7 000866202 08204 $$a616.0756$$223 000866202 24500 $$aMolecular Diagnostics in Cancer Patients /$$ceditors, Kamla Kant Shukla, Praveen Sharma and Sanjeev Misra. 000866202 264_1 $$aSingapore :$$bSpringer,$$c[2019] 000866202 300__ $$a1 online resource. 000866202 336__ $$atext$$btxt$$2rdacontent 000866202 337__ $$acomputer$$bc$$2rdamedia 000866202 338__ $$aonline resource$$bcr$$2rdacarrier 000866202 504__ $$aIncludes bibliographical references. 000866202 5050_ $$aIntro; Contents; About the Editors; 1: Recent Advances in Molecular Diagnostic Approaches for Cancer; 1.1 Introduction; 1.2 Causes of Cancer; 1.3 Classification of Cancers; 1.4 Screening of Cancer; 1.5 Diagnosis; 1.6 Molecular Biomarkers; 1.7 Various Techniques Used in Molecular Diagnostics; 1.7.1 Polymerase Chain Reaction (PCR); 1.7.2 Real-Time PCR; 1.7.3 DNA Sequencing; 1.7.4 Microarrays; 1.7.5 Cytogenetic Testing; 1.7.6 Fluorescent In Situ Hybridization (FISH); 1.7.7 Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS); 1.8 Prognosis 000866202 5058_ $$a1.9 Pharmacokinetics and Pharmacodynamics1.10 Conclusion; References; 2: Molecular Diagnosis of Gall Bladder Cancer; 2.1 Gallbladder Cancer; 2.2 Risk Factors GBC; 2.2.1 Age, Gender, Race and Socioeconomic Status; 2.2.2 Gallstone and Other Pre-existing Diseases; 2.2.3 Chronic Inflammation; 2.2.4 Infections; 2.2.5 Diet; 2.2.6 Obesity; 2.2.7 Genetic Susceptibility and Family History; 2.3 Pathogenesis of Gallbladder Cancer; 2.4 GBC Types; 2.5 Clinical Presentation; 2.6 Diagnostic Methods; 2.6.1 Blood test/Serum Markers; 2.6.2 Imaging Techniques; 2.6.3 Elastography 000866202 5058_ $$a2.6.4 PET and PET/CT2.6.5 Endoscopic retrograde cholangiopancreatography (ERCP/ERC); 2.6.6 Percutaneous Transhepatic Cholangiography (PTC); 2.6.7 Biopsy; 2.7 Molecular Markers for GBC Diagnosis and Prognosis; 2.8 Conclusion; References; 3: Molecular Diagnostics for Lung Cancer; 3.1 Introduction; 3.2 Classification of Lung Cancer; 3.3 Genetic Aberrations in Lung Cancer; 3.3.1 Epidermal Growth Factor Receptor (EGFR); 3.3.2 Anaplastic Lymphoma Kinase (ALK); 3.3.3 ROS1 (c-Ros Oncogene 1); 3.3.4 RET (Rearranged During Transfection); 3.3.5 MET 000866202 5058_ $$a3.3.6 KRAS (Kirsten Rat Sarcoma Viral Oncogene Homologue)3.3.7 PI3K (Phosphatidylinositol- 3-Kinase); 3.4 Various Techniques Used in Molecular Diagnostics; 3.4.1 Fluorescent In Situ Hybridization (FISH); 3.4.2 Immunohistochemistry (IHC); 3.4.3 Sanger Sequencing; 3.4.4 Allele-Specific PCR and Real-Time PCR; 3.5 Emerging Technologies for Molecular Diagnostics; 3.5.1 High-Throughput Multiplexing Assays; 3.5.2 Next Generation Sequencing (NGS); 3.5.3 Liquid Biopsy; 3.6 Challenges; 3.7 Quality Control for Molecular Pathology Testing for Lung Cancer; 3.7.1 Pre-analytical 000866202 5058_ $$a3.7.2 AnalyticalReferences; 4: Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors; 4.1 Introduction; 4.2 What Are Biomarkers and How Are They Helpful in the Early Diagnosis of Tumors?; 4.2.1 Prognostic Biomarkers; 4.2.2 Predictive Biomarkers; 4.2.3 Pharmacodynamic Biomarkers; 4.3 Methods, Tools and Challenges Associate with Biomarker Detection Approaches; 4.3.1 Gene Analysis; 4.3.2 Proteome Analysis; 4.3.3 Metabolite Analysis; 4.4 The Protein Quality Control Mechanism and Its Association with Cancers; 4.4.1 Autophagy 000866202 506__ $$aAccess limited to authorized users. 000866202 588__ $$aOnline resource; title from PDF title page (viewed March 20, 2019). 000866202 650_0 $$aMolecular diagnosis. 000866202 650_0 $$aCancer$$xDiagnosis$$xMolecular aspects. 000866202 650_0 $$aPathology, Molecular. 000866202 650_0 $$aCancer$$xPatients. 000866202 7001_ $$aShukla, Kamla Kant,$$eeditor. 000866202 7001_ $$aSharma, Praveen,$$eeditor. 000866202 7001_ $$aMisra, Sanjeev,$$eeditor. 000866202 77608 $$iPrint version: $$z9811358761$$z9789811358760$$w(OCoLC)1077592533 000866202 852__ $$bebk 000866202 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-13-5877-7$$zOnline Access$$91397441.1 000866202 909CO $$ooai:library.usi.edu:866202$$pGLOBAL_SET 000866202 980__ $$aEBOOK 000866202 980__ $$aBIB 000866202 982__ $$aEbook 000866202 983__ $$aOnline 000866202 994__ $$a92$$bISE