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Intro; Preface; Contents; Part I: Overview of Periostin; 1: Naming, History, Future; References; Part II: Basic Properties of Periostin; 2: The Structure of the Periostin Gene, Its Transcriptional Control and Alternative Splicing, and Protein Expression; 2.1 The Gene Structure; 2.1.1 Mouse or Human Periostin Gene; 2.1.2 Alternative Splicing of the Mouse or Human Periostin Gene; 2.1.3 Other Vertebral Periostin Genes; 2.2 Transcription Control; 2.2.1 Transactivator and Cis-Element; 2.2.2 Factors Inducing Periostin Expression; 2.3 Protein
3.1 The EMI Domain of Periostin Is Responsible for Multimerization and Interacts with Extracellular Matrix Proteins3.2 The Tandem Repeat of Four FAS 1 Domains of Periostin Binds to Tenascin, BMP-1, and CCN3; 3.3 The CTD Possesses an Arg-Rich Region Responsible for Binding to Proteoglycans; 3.4 Conclusion; References; Part IV: Health and Disease in Organs; 4: Periostin Reexpression in Heart Disease Contributes to Cardiac Interstitial Remodeling by Supporting the Cardiac Myofibroblast Phenotype; 4.1 Introduction; 4.2 Periostin as a Regulator of Cardiac ECM
4.2.1 Previously Unrecognized Interstitium in the Vascular Adventitia - A New Look at the Role for Periostin in Vascular Disease?4.2.2 Cardiac Regeneration and the Putative Role of Periostin; 4.2.3 Periostin as a Marker of Activated Myofibroblasts; 4.3 Heart Disease and Periostin - Future Research and Treatment Modalities for Heart Failure; 4.3.1 Myocardial Infarction - The Current Problem and Possible Research Directions; 4.3.2 Future Directions; 4.4 Synopsis; References; 5: Periostin in Bone Biology; 5.1 Expression of Periostin in Bone; 5.2 Abnormal Bone in Periostin Deficient Mice
5.3 Periostin in Collagen Cross-Linking5.4 Periostin in Mechanical Stress; 5.5 Periotin in Future; References; 6: Periostin in Bone Regeneration; 6.1 Introduction; 6.2 Bone Regeneration after Fracture; 6.3 Role of Periosteum in Bone Repair; 6.4 Periosteal Cells Express Periostin in Response to Bone Injury; 6.5 Periostin Is Required for Bone Repair; 6.6 Periostin Regulates the Skeletal Stem Cell Niche Within Periosteum; 6.7 Clinical Applications Using Periosteal Cells and Periostin in Bone Repair; References
3.1 The EMI Domain of Periostin Is Responsible for Multimerization and Interacts with Extracellular Matrix Proteins3.2 The Tandem Repeat of Four FAS 1 Domains of Periostin Binds to Tenascin, BMP-1, and CCN3; 3.3 The CTD Possesses an Arg-Rich Region Responsible for Binding to Proteoglycans; 3.4 Conclusion; References; Part IV: Health and Disease in Organs; 4: Periostin Reexpression in Heart Disease Contributes to Cardiac Interstitial Remodeling by Supporting the Cardiac Myofibroblast Phenotype; 4.1 Introduction; 4.2 Periostin as a Regulator of Cardiac ECM
4.2.1 Previously Unrecognized Interstitium in the Vascular Adventitia - A New Look at the Role for Periostin in Vascular Disease?4.2.2 Cardiac Regeneration and the Putative Role of Periostin; 4.2.3 Periostin as a Marker of Activated Myofibroblasts; 4.3 Heart Disease and Periostin - Future Research and Treatment Modalities for Heart Failure; 4.3.1 Myocardial Infarction - The Current Problem and Possible Research Directions; 4.3.2 Future Directions; 4.4 Synopsis; References; 5: Periostin in Bone Biology; 5.1 Expression of Periostin in Bone; 5.2 Abnormal Bone in Periostin Deficient Mice
5.3 Periostin in Collagen Cross-Linking5.4 Periostin in Mechanical Stress; 5.5 Periotin in Future; References; 6: Periostin in Bone Regeneration; 6.1 Introduction; 6.2 Bone Regeneration after Fracture; 6.3 Role of Periosteum in Bone Repair; 6.4 Periosteal Cells Express Periostin in Response to Bone Injury; 6.5 Periostin Is Required for Bone Repair; 6.6 Periostin Regulates the Skeletal Stem Cell Niche Within Periosteum; 6.7 Clinical Applications Using Periosteal Cells and Periostin in Bone Repair; References