Linked e-resources
Details
Table of Contents
Intro; Preface; Contents; Chapter 1: Acoustofluidic Blood Component Sample Preparation and Processing in Medical Applications; 1.1 Introduction; 1.1.1 Acoustofluidics; 1.1.1.1 Primary Acoustic Radiation Force; 1.1.1.2 Two-Dimensional Focusing; 1.1.1.3 Acoustic Streaming; 1.1.1.4 Size-Insensitive Separation; 1.1.1.5 Medium Switching; 1.1.1.6 Biocompatibility; 1.2 Blood Components; 1.2.1 Platelets; 1.2.2 WBC Sub-populations; 1.2.2.1 Integrated Acoustic Device for Monocyte Subpopulation Isolation; 1.2.3 Plasma and Plasma Proteins; 1.2.4 RBC Separation; 1.2.5 Hematocrit Measurements
1.3 Circulating Tumor Cells1.3.1 Cancer Cell Separation Based on a Positive Acoustic Contrast Factor; 1.3.2 Cancer Cell Separation Based on a Negative Acoustic Contrast Factor; 1.3.3 Cancer Cell Concentration; 1.3.4 Integrated Acoustic Devices for CTC Processing; 1.4 Bacteria; 1.4.1 Passive Bacteria Processing; 1.4.2 Active Bacteria Processing; 1.5 Conclusions; References; Chapter 2: Microfluidic Technologies and Platforms for Protein Crystallography; 2.1 Introduction; 2.2 Principle of the Protein Crystallization and X-Ray Diffraction Measurement
2.3 Microfluidic Devices for High-Throughput Screening of Protein Crystallization Condition2.4 Protein Crystal Growth in a Microspace Environment; 2.5 On-Chip Protein Crystal Structure Analysis and Other Applications; 2.6 Summary; References; Chapter 3: Application of SERS-Based Microfluidics for In Vitro Diagnostics; 3.1 Introduction; 3.2 Multiplex Immunoassay Using Array-Embedded Microfluidic Channel; 3.3 Magnetic Bead-Based Immunoassay in Microfluidic Channel; 3.4 Segmented Flow-Based Immunoassay in Microfluidic Channel; 3.5 Summary; References
Chapter 4: Miniaturized Electrochemical Sensors to Facilitate Liquid Biopsy for Detection of Circulating Tumor Markers4.1 Introduction; 4.1.1 Circulating Tumor Markers; 4.1.2 Why Electrochemistry; 4.2 Circulating Tumor Cells; 4.3 Circulgating Nucleic Acids; 4.4 Extracellular Vesicles; 4.5 Conclusions and Perspectives; References; Chapter 5: Spiral Inertial Microfluidics for Cell Separation and Biomedical Applications; 5.1 Introduction; 5.1.1 Conventional Separation Techniques; 5.1.2 Microfluidics Cell Separation; 5.2 Theory; 5.2.1 Stokes Flow; 5.2.2 Inertial Focusing
5.2.2.1 Wall Induced Lift Force (FWL)5.2.2.2 Shear Gradient Lift Force (FSL); 5.2.2.3 Net Lift Force (FL); 5.2.2.4 Secondary-Flow Drag Force; 5.2.2.5 Dynamics of Particle Lateral Migration in Spiral Microchannel; 5.3 Classification of Spiral Devices; 5.3.1 Rectangular Spiral Microfluidics; 5.3.2 Trapezoidal Spiral Microfluidics; 5.3.3 Double-Inlet Spiral/ Dean Flow Fractionation (DFF); 5.3.4 High-Resolution Dean Flow Fractionation (HiDFF); 5.3.5 Summary; 5.4 Cell Applications; 5.4.1 Cancer Cells; 5.4.2 Stem Cells; 5.4.3 Immune Cells; 5.4.4 Sperm Cells; 5.4.5 Microbes; 5.4.6 Biomolecules
1.3 Circulating Tumor Cells1.3.1 Cancer Cell Separation Based on a Positive Acoustic Contrast Factor; 1.3.2 Cancer Cell Separation Based on a Negative Acoustic Contrast Factor; 1.3.3 Cancer Cell Concentration; 1.3.4 Integrated Acoustic Devices for CTC Processing; 1.4 Bacteria; 1.4.1 Passive Bacteria Processing; 1.4.2 Active Bacteria Processing; 1.5 Conclusions; References; Chapter 2: Microfluidic Technologies and Platforms for Protein Crystallography; 2.1 Introduction; 2.2 Principle of the Protein Crystallization and X-Ray Diffraction Measurement
2.3 Microfluidic Devices for High-Throughput Screening of Protein Crystallization Condition2.4 Protein Crystal Growth in a Microspace Environment; 2.5 On-Chip Protein Crystal Structure Analysis and Other Applications; 2.6 Summary; References; Chapter 3: Application of SERS-Based Microfluidics for In Vitro Diagnostics; 3.1 Introduction; 3.2 Multiplex Immunoassay Using Array-Embedded Microfluidic Channel; 3.3 Magnetic Bead-Based Immunoassay in Microfluidic Channel; 3.4 Segmented Flow-Based Immunoassay in Microfluidic Channel; 3.5 Summary; References
Chapter 4: Miniaturized Electrochemical Sensors to Facilitate Liquid Biopsy for Detection of Circulating Tumor Markers4.1 Introduction; 4.1.1 Circulating Tumor Markers; 4.1.2 Why Electrochemistry; 4.2 Circulating Tumor Cells; 4.3 Circulgating Nucleic Acids; 4.4 Extracellular Vesicles; 4.5 Conclusions and Perspectives; References; Chapter 5: Spiral Inertial Microfluidics for Cell Separation and Biomedical Applications; 5.1 Introduction; 5.1.1 Conventional Separation Techniques; 5.1.2 Microfluidics Cell Separation; 5.2 Theory; 5.2.1 Stokes Flow; 5.2.2 Inertial Focusing
5.2.2.1 Wall Induced Lift Force (FWL)5.2.2.2 Shear Gradient Lift Force (FSL); 5.2.2.3 Net Lift Force (FL); 5.2.2.4 Secondary-Flow Drag Force; 5.2.2.5 Dynamics of Particle Lateral Migration in Spiral Microchannel; 5.3 Classification of Spiral Devices; 5.3.1 Rectangular Spiral Microfluidics; 5.3.2 Trapezoidal Spiral Microfluidics; 5.3.3 Double-Inlet Spiral/ Dean Flow Fractionation (DFF); 5.3.4 High-Resolution Dean Flow Fractionation (HiDFF); 5.3.5 Summary; 5.4 Cell Applications; 5.4.1 Cancer Cells; 5.4.2 Stem Cells; 5.4.3 Immune Cells; 5.4.4 Sperm Cells; 5.4.5 Microbes; 5.4.6 Biomolecules