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000890703 019__ $$a1105182938
000890703 020__ $$a9783030151386$$q(electronic book)
000890703 020__ $$a3030151387$$q(electronic book)
000890703 020__ $$z9783030151409
000890703 0247_ $$a10.1007/978-3-030-15
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000890703 035__ $$aSP(OCoLC)1103218660$$z(OCoLC)1105182938
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000890703 24500 $$aMolecular mechanisms of inflammation :$$binduction, resolution and escape by Helicobacter pylori /$$cSteffen Backert, editor.
000890703 260__ $$aCham :$$bSpringer,$$c2019.
000890703 300__ $$a1 online resource (378 pages).
000890703 336__ $$atext$$btxt$$2rdacontent
000890703 337__ $$acomputer$$bc$$2rdamedia
000890703 338__ $$aonline resource$$bcr$$2rdacarrier
000890703 4901_ $$aCurrent Topics in Microbiology and Immunology ;$$vv.421
000890703 5050_ $$aInflammation, immunity and vaccine development for the gastric pathogen Helicobacter pylori -- Impact of Helicobacter pylori Virulence Factors on the Host immune Response and Gastric Pathology -- Genetic polymorphisms in inflammatory and other regulators in gastric cancer: risks and clinical consequences -- MALT lymphoma as a model of chronic inflammation-induced gastric tumor development -- Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis -- Importance of toll-like receptors in pro-inflammatory and anti-inflammatory responses by Helicobacter pylori infection -- Role of NOD1 and ALPK1/TIFA signalling in innate immunity against Helicobacter pylori infection -- Carbohydrate-dependent and antimicrobial peptide defense mechanisms against Helicobacter pylori infections -- The sweeping role of cholesterol depletion in the persistence of Helicobacter pylori infections -- Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion -- Mechanisms of inflammasome signaling, microRNA induction and resolution of inflammation by Helicobacter pylori -- Impact of the gastrointestinal microbiome in health and disease: co-evolution with the host immune system -- Resolution of gastric cancer-promoting inflammation: a novel strategy for anti-cancer therapy.
000890703 506__ $$aAccess limited to authorized users.
000890703 520__ $$aThis book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the worlds population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.
000890703 588__ $$aDescription based on print version record.
000890703 650_0 $$aHelicobacter pylori infections.
000890703 7001_ $$aBackert, Steffen.
000890703 77608 $$iPrint version:$$aBackert, Steffen$$tMolecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter Pylori$$dCham : Springer,c2019$$z9783030151379
000890703 830_0 $$aCurrent topics in microbiology and immunology ;$$vv. 421.
000890703 852__ $$bebk
000890703 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-15138-6$$zOnline Access$$91397441.1
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000890703 980__ $$aBIB
000890703 982__ $$aEbook
000890703 983__ $$aOnline
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