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Intro; Contents; 1: Management-Based Pathology Assessment of Salivary Gland Carcinomas; 1.1 Introduction; 1.2 Salivary Gland Development and Tumorigenesis; 1.3 Classification; 1.4 Pre-surgical Diagnosis of Salivary Gland Tumors; 1.4.1 Fine Needle Aspirations (Table 1.2); 1.4.2 Core Biopsy; 1.4.3 Intraoperative Consultations; 1.5 Post Surgical Gross Assessment; 1.5.1 Histopathologic Evaluation; 1.5.2 Pathologic Report; 1.6 Common Benign Salivary Gland Tumors of Differential Diagnostic Significance; 1.6.1 Pleomorphic Adenoma (PA); 1.6.2 Myoepithelioma
1.6.3 Basal Cell Salivary Adenoma1.6.4 Oncocytic Salivary Lesion; 1.6.5 Warthin's Tumor (WT); 1.7 Malignant Salivary Tumors; 1.7.1 Mucoepidermoid Carcinoma (MEC); 1.7.2 Adenoid Cystic Carcinoma (ACC); 1.7.3 Salivary Duct Carcinoma (De Novo and Ex-pleomorphic Adenoma); 1.7.4 Polymorphous Adenocarcinoma (PAC); 1.7.5 Acinic Cell Carcinoma; 1.7.6 Secretory Carcinoma; 1.7.7 Adenocarcinoma: Not Otherwise Specified (NOS); 1.7.8 Basal Cell Adenocarcinoma (BCAC); 1.7.9 Clear Cell Carcinoma (CCC); 1.7.10 Myoepithelial Carcinoma; 1.7.11 Epithelial-Myoepithelial Carcinoma (EMC)
1.7.12 Carcinosarcoma1.7.13 Poorly Differentiated and Undifferentiated Carcinomas; 1.7.14 Undifferentiated (Lymphoepithelial) Carcinoma; 1.7.15 Primary Squamous Carcinoma; 1.7.16 Sialoblastoma; References; 2: Molecular Characterization of Salivary Gland Carcinomas; 2.1 Introduction; 2.2 Mucoepidermoid Carcinoma; 2.3 Adenoid Cystic Carcinoma; 2.4 Mammary Analogue Secretory Carcinoma; 2.5 Hyalinizing Clear-Cell Carcinoma; 2.6 Carcinoma Ex Pleomorphic Adenoma; 2.7 Salivary Duct Carcinoma and Low-Grade Intraductal Carcinoma; 2.8 Acinic Cell Carcinoma
2.9 Polymorphous Adenocarcinoma and Cribriform Adenocarcinoma2.10 Conclusions; References; 3: The Role of Imaging in Staging and Follow-Up of Salivary Gland Tumors; 3.1 Introduction; 3.2 Ultrasound; 3.2.1 Benign Neoplasm; 3.2.2 Malignant Neoplasms; 3.3 Magnetic Resonance Imaging; 3.4 Additional MR Imaging Techniques; 3.5 Computed Tomography; 3.6 Perineural Spread; 3.7 Follow-Up of Salivary Gland Tumors; 3.8 Positron Emission Tomography-CT with Fluorine-18-Deoxy-d-Glucose (FDG PET-CT); References; 4: Surgery for Malignant Parotid Gland Tumours; 4.1 Introduction
4.2 Surgery for Primary Parotid Cancer4.2.1 Workup: Diagnostic Radiology; 4.2.2 Workup: Pretreatment Pathology; 4.2.3 Extent of Surgery for the Primary Tumour; 4.2.3.1 Less-Than-Total Parotidectomy (Nos. 1 and 2); 4.2.3.2 Total Conservative Parotidectomy (No. 3) (Fig. 4.3); 4.2.3.3 Nerve Sacrifying Total Parotidectomy (No. 4 and Higher) (Fig. 4.4); 4.2.3.4 Extended Parotidectomies: Reconstructive Issues Regarding the Skin and Soft Tissue (Fig. 4.5); 4.2.4 Surgery for Cancer Metastatic to the Parotid; 4.2.5 Treatment of the Neck; 4.2.5.1 The cN+ Neck; 4.2.5.2 The cN0 Neck
1.6.3 Basal Cell Salivary Adenoma1.6.4 Oncocytic Salivary Lesion; 1.6.5 Warthin's Tumor (WT); 1.7 Malignant Salivary Tumors; 1.7.1 Mucoepidermoid Carcinoma (MEC); 1.7.2 Adenoid Cystic Carcinoma (ACC); 1.7.3 Salivary Duct Carcinoma (De Novo and Ex-pleomorphic Adenoma); 1.7.4 Polymorphous Adenocarcinoma (PAC); 1.7.5 Acinic Cell Carcinoma; 1.7.6 Secretory Carcinoma; 1.7.7 Adenocarcinoma: Not Otherwise Specified (NOS); 1.7.8 Basal Cell Adenocarcinoma (BCAC); 1.7.9 Clear Cell Carcinoma (CCC); 1.7.10 Myoepithelial Carcinoma; 1.7.11 Epithelial-Myoepithelial Carcinoma (EMC)
1.7.12 Carcinosarcoma1.7.13 Poorly Differentiated and Undifferentiated Carcinomas; 1.7.14 Undifferentiated (Lymphoepithelial) Carcinoma; 1.7.15 Primary Squamous Carcinoma; 1.7.16 Sialoblastoma; References; 2: Molecular Characterization of Salivary Gland Carcinomas; 2.1 Introduction; 2.2 Mucoepidermoid Carcinoma; 2.3 Adenoid Cystic Carcinoma; 2.4 Mammary Analogue Secretory Carcinoma; 2.5 Hyalinizing Clear-Cell Carcinoma; 2.6 Carcinoma Ex Pleomorphic Adenoma; 2.7 Salivary Duct Carcinoma and Low-Grade Intraductal Carcinoma; 2.8 Acinic Cell Carcinoma
2.9 Polymorphous Adenocarcinoma and Cribriform Adenocarcinoma2.10 Conclusions; References; 3: The Role of Imaging in Staging and Follow-Up of Salivary Gland Tumors; 3.1 Introduction; 3.2 Ultrasound; 3.2.1 Benign Neoplasm; 3.2.2 Malignant Neoplasms; 3.3 Magnetic Resonance Imaging; 3.4 Additional MR Imaging Techniques; 3.5 Computed Tomography; 3.6 Perineural Spread; 3.7 Follow-Up of Salivary Gland Tumors; 3.8 Positron Emission Tomography-CT with Fluorine-18-Deoxy-d-Glucose (FDG PET-CT); References; 4: Surgery for Malignant Parotid Gland Tumours; 4.1 Introduction
4.2 Surgery for Primary Parotid Cancer4.2.1 Workup: Diagnostic Radiology; 4.2.2 Workup: Pretreatment Pathology; 4.2.3 Extent of Surgery for the Primary Tumour; 4.2.3.1 Less-Than-Total Parotidectomy (Nos. 1 and 2); 4.2.3.2 Total Conservative Parotidectomy (No. 3) (Fig. 4.3); 4.2.3.3 Nerve Sacrifying Total Parotidectomy (No. 4 and Higher) (Fig. 4.4); 4.2.3.4 Extended Parotidectomies: Reconstructive Issues Regarding the Skin and Soft Tissue (Fig. 4.5); 4.2.4 Surgery for Cancer Metastatic to the Parotid; 4.2.5 Treatment of the Neck; 4.2.5.1 The cN+ Neck; 4.2.5.2 The cN0 Neck