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000890895 019__ $$a1104082371$$a1105179277
000890895 020__ $$a9783030142650$$q(electronic book)
000890895 020__ $$a3030142655$$q(electronic book)
000890895 020__ $$z3030142647
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000890895 0248_ $$a10.1007/978-3-030-14
000890895 035__ $$aSP(OCoLC)on1103502985
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000890895 050_4 $$aQP752.C5$$bD57 2019
000890895 08204 $$a572/.5795$$223
000890895 24500 $$aDirect mechanisms in cholesterol modulation of protein function /$$cAvia Rosenhouse-Dantsker, Anna N. Bukiya, editors.
000890895 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2019]
000890895 300__ $$a1 online resource
000890895 336__ $$atext$$btxt$$2rdacontent
000890895 337__ $$acomputer$$bc$$2rdamedia
000890895 338__ $$aonline resource$$bcr$$2rdacarrier
000890895 4901_ $$aAdvances in Experimental Medicine and Biology Ser. ;$$vvolume 1135
000890895 5050_ $$aIntroduction -- Direct binding of cholesterol to proteins -- Cholesterol-recognition motifs in membrane proteins -- Molecular determinants of cholesterol binding to proteins: overview of crystallographic studies -- Crystallographic studies of steroid-protein interactions -- Insights into cholesterol binding sites in proteins from computational studies -- Cholesterol binding to NPC1/NPC2 -- I Biophysical elements of the interaction between cholesterol and the nicotinic acetylcholine receptor -- Modulation of TRPV1 channels by cholesterol -- Cholesterol binding sites in inwardly rectifying potassium channels.
000890895 506__ $$aAccess limited to authorized users.
000890895 520__ $$aIn this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins. The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
000890895 588__ $$aDescription based on online resource; title from digital title page (viewed on June 24, 2019).
000890895 650_0 $$aCholesterol.
000890895 7001_ $$aRosenhouse-Dantsker, Avia,$$eeditor.
000890895 7001_ $$aBukiya, Anna N.,$$eeditor.
000890895 77608 $$iPrint version $$z3030142647$$z9783030142643$$w(OCoLC)1084337631
000890895 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1135.
000890895 852__ $$bebk
000890895 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-14265-0$$zOnline Access$$91397441.1
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000890895 980__ $$aEBOOK
000890895 980__ $$aBIB
000890895 982__ $$aEbook
000890895 983__ $$aOnline
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