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000891260 019__ $$a1105170982
000891260 020__ $$a9783030178642$$q(electronic book)
000891260 020__ $$a3030178641$$q(electronic book)
000891260 0247_ $$a10.1007/978-3-030-17$$2doi
000891260 035__ $$aSP(OCoLC)on1103219233
000891260 035__ $$aSP(OCoLC)1103219233$$z(OCoLC)1105170982
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000891260 050_4 $$aRC268.3$$b.G37 2019
000891260 08204 $$a616.99/4079$$223
000891260 1001_ $$aGarrido, Federico,$$eauthor.
000891260 24510 $$aMHC Class-I loss and cancer immune escape /$$cFederico Garrido.
000891260 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2019]
000891260 300__ $$a1 online resource :$$billustrations
000891260 336__ $$atext$$btxt$$2rdacontent
000891260 337__ $$acomputer$$bc$$2rdamedia
000891260 338__ $$aonline resource$$bcr$$2rdacarrier
000891260 4901_ $$aAdvances in experimental medicine and biology ;$$vvolume 1151
000891260 504__ $$aIncludes bibliographical references and index.
000891260 5050_ $$aPreface -- Introduction -- Mhc/Hla Class I Loss In Cancer Cells -- Hla Class-I Expression And Cancer Immunotherapy -- Hla Class-Ii Expression In Human Tumors -- Index.
000891260 506__ $$aAccess limited to authorized users.
000891260 520__ $$aThis book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the "Antigen Presenting Molecules" and the "T Lymphocytes". The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between "self and non self". Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast...ect. as well as melanoma and lymphoma. This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in "Tumor Immunology".
000891260 588__ $$aDescription based on online resource; title from digital title page (viewed on June 25, 2019).
000891260 650_0 $$aCancer$$xImmunological aspects.
000891260 77608 $$iPrint version:$$aGarrido, Federico$$tMHC Class-I Loss and Cancer Immune Escape$$dCham : Springer,c2019$$z9783030178635
000891260 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1151.
000891260 852__ $$bebk
000891260 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-17864-2$$zOnline Access$$91397441.1
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000891260 980__ $$aEBOOK
000891260 980__ $$aBIB
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000891260 983__ $$aOnline
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