Carbonic anhydrase as drug target : thermodynamics and structure of inhibitor binding / Daumantas Matulis, editor.

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Carbonic anhydrase as drug target : thermodynamics and structure of inhibitor binding / Daumantas Matulis, editor.

9783030127800 (electronic book)
303012780X (electronic book)
9783030127787

Cham, Switzerland : Springer, [2019]

English

1 online resource (358 pages)

10.1007/978-3-030-12 doi

QP613.C37 C37 2019

572/.7
611.01816

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.

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Description based on online resource; title from digital title page (viewed on July 11, 2019).

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