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Intro; Acknowledgment; Abbreviations; Contents; 1: Introduction; References; 2: The Emerging Medical Landscape; 2.1 The Overwhelming Human Responsibility; 2.2 The Two Recent Epidemiological Transitions; 2.2.1 Throughout the World; 2.3 The Emergencies; 2.3.1 The Two Out-Of-Control Risks: Nuclear Power and Poverty; 2.3.2 Age, the First of the Emerging Risks; 2.3.3 Incidence of Non-Transmissible Chronic Diseases; 2.3.4 Other Age-Linked Diseases; References; 3: The Origins of Ageing; 3.1 Genome Instability; 3.2 Genetics and Heredity; 3.3 Telomeres and Telomerase; 3.4 Proteostasis
3.5 Epigenetics3.6 Microbiota; References; 4: The Senescent Cell, SC; 4.1 The Overview; 4.2 Consequences of Stem/Precursor Cell Proliferation Arrest; 4.3 The SC Secretome; 4.4 Fibrosis; References; 5: The Nonfatal Clinical Manifestations of Ageing; 5.1 Hair, Skin, Adipose Tissue; 5.2 Bones, Muscles, and Joints; 5.3 General Conditions, Frailty Syndrome, Fluid Balance, Immune System; 5.4 Biological Rhythms; 5.5 The Senses and Sensitivity; References; 6: Age-Linked Non-Transmissible Diseases; 6.1 Cancers; 6.2 Neurodegenerative Diseases; 6.3 Type 2 Diabetes and Metabolic Syndrome
6.4 Lungs, Kidneys and Liver Diseases6.5 The Senescent CV System; 6.5.1 The Senescent Myocardium; 6.5.2 The Senescent Vascular System; 6.5.3 Consequences of Change in Characteristic Arterial Impedance; 6.5.4 The Clinical Manifestations of Atherosclerosis; 6.5.5 Heart Failure in Senescence; 6.5.6 Atrial Fibrillation; References; 7: How to Treat or Prevent, or Slow Down, Cellular Ageing and Senescence?; 7.1 The Various Attempts at Reprogramming; 7.2 Calorie Restriction; 7.3 Physical Exercise; References; 8: Senescence: A Darwinian Evolutionary Perspective
8.1 Genetic Versus Environmental Factors in Senescence8.2 Senescence and Inflammation; References; 9: Conclusions; 9.1 The Accession of Gerontechnologies; 9.2 The Adaptive Capacities; 9.3 The Gerontological Aspects of the Making of Ignorance; References; 10: Summary; References; Annex A: Senescence in Plants and Bacteria; Annex B: Theories of Ageing; Complexity: Is Senescence Linked to a Loss of the Complexity That Is Inherently Linked to Life?; Annex C: Telomeres and Telomerase; Annex D: MicroRNAs, miRs; Annex E: Circadian Rhythms, a Fundamental Basis of Life; The Hypothalamic Clock
Molecular MechanismsThe Peripheral Clocks; The Different Biological Rhythms: Sleep/Wakefulness; Hormones; Temperature; Molecular Correlations; Cell Physiology; Annex F: The Diabetic Heart; From a Biological Point of View; Glossary; References
3.5 Epigenetics3.6 Microbiota; References; 4: The Senescent Cell, SC; 4.1 The Overview; 4.2 Consequences of Stem/Precursor Cell Proliferation Arrest; 4.3 The SC Secretome; 4.4 Fibrosis; References; 5: The Nonfatal Clinical Manifestations of Ageing; 5.1 Hair, Skin, Adipose Tissue; 5.2 Bones, Muscles, and Joints; 5.3 General Conditions, Frailty Syndrome, Fluid Balance, Immune System; 5.4 Biological Rhythms; 5.5 The Senses and Sensitivity; References; 6: Age-Linked Non-Transmissible Diseases; 6.1 Cancers; 6.2 Neurodegenerative Diseases; 6.3 Type 2 Diabetes and Metabolic Syndrome
6.4 Lungs, Kidneys and Liver Diseases6.5 The Senescent CV System; 6.5.1 The Senescent Myocardium; 6.5.2 The Senescent Vascular System; 6.5.3 Consequences of Change in Characteristic Arterial Impedance; 6.5.4 The Clinical Manifestations of Atherosclerosis; 6.5.5 Heart Failure in Senescence; 6.5.6 Atrial Fibrillation; References; 7: How to Treat or Prevent, or Slow Down, Cellular Ageing and Senescence?; 7.1 The Various Attempts at Reprogramming; 7.2 Calorie Restriction; 7.3 Physical Exercise; References; 8: Senescence: A Darwinian Evolutionary Perspective
8.1 Genetic Versus Environmental Factors in Senescence8.2 Senescence and Inflammation; References; 9: Conclusions; 9.1 The Accession of Gerontechnologies; 9.2 The Adaptive Capacities; 9.3 The Gerontological Aspects of the Making of Ignorance; References; 10: Summary; References; Annex A: Senescence in Plants and Bacteria; Annex B: Theories of Ageing; Complexity: Is Senescence Linked to a Loss of the Complexity That Is Inherently Linked to Life?; Annex C: Telomeres and Telomerase; Annex D: MicroRNAs, miRs; Annex E: Circadian Rhythms, a Fundamental Basis of Life; The Hypothalamic Clock
Molecular MechanismsThe Peripheral Clocks; The Different Biological Rhythms: Sleep/Wakefulness; Hormones; Temperature; Molecular Correlations; Cell Physiology; Annex F: The Diabetic Heart; From a Biological Point of View; Glossary; References