Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks
Title
Hypoxia and cancer metastasis / editor Daniele M. Gilkes.
ISBN
9783030127343 (electronic book)
3030127346 (electronic book)
9783030127336
Published
Cham, Switzerland : Springer, [2019]
Copyright
©2019
Language
English
Description
1 online resource.
Item Number
10.1007/978-3-030-12
Call Number
RA645.C3
Dewey Decimal Classification
614.5999
Summary
The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Vendor-supplied metadata.
Series
Advances in experimental medicine and biology ; v. 1136.
Preface
Hypoxia mediates tumor malignancy
Clinical methods for quanitifying hypoxia in human tumors
Hypoxia-induced phenotypes that mediate tumor heterogeneity
Hypoxia and the tumors secretome
Hypoxic signaling in angiogenesis and lymphangiogenesis
Hypoxia induced metabolic reprogramming in cancer metastasis
The metastatic niche and hypoxia
Hypoxia and immune suppression
Hypoxia-induced resistance to cancer therapy
Therapeutic stratagies to target the hypoxic microenvironment
Index.
