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000891461 019__ $$a1106164448
000891461 020__ $$a9783030127343$$q(electronic book)
000891461 020__ $$a3030127346$$q(electronic book)
000891461 020__ $$z9783030127336
000891461 0248_ $$a10.1007/978-3-030-12
000891461 035__ $$aSP(OCoLC)on1104790217
000891461 035__ $$aSP(OCoLC)1104790217$$z(OCoLC)1106164448
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000891461 049__ $$aISEA
000891461 050_4 $$aRA645.C3
000891461 08204 $$a614.5999$$223
000891461 24500 $$aHypoxia and cancer metastasis /$$ceditor Daniele M. Gilkes.
000891461 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2019]
000891461 264_4 $$c©2019
000891461 300__ $$a1 online resource.
000891461 336__ $$atext$$btxt$$2rdacontent
000891461 337__ $$acomputer$$bc$$2rdamedia
000891461 338__ $$aonline resource$$bcr$$2rdacarrier
000891461 4901_ $$aAdvances in experimental medicine and biology ;$$vVolume 1136
000891461 504__ $$aIncludes bibliographical references and index.
000891461 5050_ $$aPreface -- Hypoxia mediates tumor malignancy -- Clinical methods for quanitifying hypoxia in human tumors -- Hypoxia-induced phenotypes that mediate tumor heterogeneity -- Hypoxia and the tumors secretome -- Hypoxic signaling in angiogenesis and lymphangiogenesis -- Hypoxia induced metabolic reprogramming in cancer metastasis -- The metastatic niche and hypoxia -- Hypoxia and immune suppression -- Hypoxia-induced resistance to cancer therapy -- Therapeutic stratagies to target the hypoxic microenvironment -- Index.
000891461 506__ $$aAccess limited to authorized users.
000891461 520__ $$aThe present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.
000891461 588__ $$aVendor-supplied metadata.
000891461 650_0 $$aCancer.
000891461 650_0 $$aAnoxemia.
000891461 650_0 $$aOxygen in the body.
000891461 7001_ $$aGilkes, Daniele M.,$$eeditor.
000891461 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1136.
000891461 852__ $$bebk
000891461 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-12734-3$$zOnline Access$$91397441.1
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000891461 980__ $$aEBOOK
000891461 980__ $$aBIB
000891461 982__ $$aEbook
000891461 983__ $$aOnline
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