@article{891510,
      recid = {891510},
      author = {Fülöp, Tamas, and Franceschi, Claudio, and Hirokawa,  Katsuiku, and Pawelec, G.},
      title = {Handbook of immunosenescence : basic understanding and  clinical implications /},
      pages = {1 online resource},
      note = {Includes index.},
      abstract = {Immunosenescence is an imprecise term used to describe  deleterious age-associated changes to immune parameters  observed in all mammals studied so far. It represents a  rapidly progressing science in the aging field, with a  vertiginous volume of new data, knowledge and concepts  concerning these changes. We are poised to be in a position  to translate these accumulated data into the clinical  setting via better understanding of the contribution of  immunosenescence to age-associated pathologies, and their  prevention by appropriate interventions. This authoritative  handbook seeks to encompass the current state of our  knowledge on the multitude of those changes to immunity  related to aging, with contributions from experts in the  research and clinical areas. This book therefore considers  methods and models for studying immunosenescence; cellular  immunosenescence of T cells, B cells, neutrophils, antigen  presenting cells, NK, NKT and stem cells; genetics;  mechanisms including receptors and signal transduction;  mitochondria; proteasome; cytokines; neuro-endocrine-immune  networks; inflammation; thymus; clinical relevance in  disease states including infections, autoimmunity, cancer,  metabolic syndrome, neurodegenerative diseases, frailty and  osteoporosis; modulation by nutrition, lipids, vaccination  and the question "can interventions to influence  immunosenescence be realistically proposed based on our  current state of knowledge?".},
      url = {http://library.usi.edu/record/891510},
      doi = {https://doi.org/10.1007/978-3-319-99},
}