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000891510 020__ $$a9783319993751$$q(electronic book)
000891510 020__ $$a3319993755$$q(electronic book)
000891510 020__ $$z9783319993737
000891510 020__ $$z9783319993744
000891510 0247_ $$a10.1007/978-3-319-99$$2doi
000891510 035__ $$aSP(OCoLC)on1105181126
000891510 035__ $$aSP(OCoLC)1105181126
000891510 040__ $$aLQU$$beng$$erda$$cLQU$$dGW5XE$$dYDXIT
000891510 049__ $$aISEA
000891510 050_4 $$aQR182$$b.H36 2019
000891510 08204 $$a616.07/9$$223
000891510 24500 $$aHandbook of immunosenescence :$$bbasic understanding and clinical implications /$$cTamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec, editors.
000891510 250__ $$aSecond edition.
000891510 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2019]
000891510 300__ $$a1 online resource
000891510 336__ $$atext$$btxt$$2rdacontent
000891510 337__ $$acomputer$$bc$$2rdamedia
000891510 338__ $$aonline resource$$bcr$$2rdacarrier
000891510 500__ $$aIncludes index.
000891510 5050_ $$aMethods and Models for Studying Immunosenescence -- Methods for studying human immunosenescence in tissues other than blood -- Mechanisms -- Receptors and Signal Transduction -- Clinical Relevance in Disease States - Infection -- Modulation -- Nutrition.
000891510 506__ $$aAccess limited to authorized users.
000891510 520__ $$aImmunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question "can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?".
000891510 588__ $$aDescription based on online resource; title from digital title page (viewed on July 08, 2019).
000891510 650_0 $$aImmune system$$xAging.
000891510 7001_ $$aFülöp, Tamas,$$d1953-$$eeditor.
000891510 7001_ $$aFranceschi, Claudio,$$eeditor.
000891510 7001_ $$aHirokawa, Katsuiku,$$eeditor.
000891510 7001_ $$aPawelec, G.$$q(Graham),$$eeditor.
000891510 85280 $$bebk$$hSpringerLink
000891510 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-99375-1$$zOnline Access$$91397441.1
000891510 909CO $$ooai:library.usi.edu:891510$$pGLOBAL_SET
000891510 980__ $$aEBOOK
000891510 980__ $$aBIB
000891510 982__ $$aEbook
000891510 983__ $$aOnline
000891510 994__ $$a92$$bISE