Handbook of immunosenescence : basic understanding and clinical implications / Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec, editors.
2019
QR182 .H36 2019
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Title
Handbook of immunosenescence : basic understanding and clinical implications / Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec, editors.
Edition
Second edition.
ISBN
9783319993751 (electronic book)
3319993755 (electronic book)
9783319993737
9783319993744
3319993755 (electronic book)
9783319993737
9783319993744
Published
Cham, Switzerland : Springer, [2019]
Language
English
Description
1 online resource
Item Number
10.1007/978-3-319-99 doi
Call Number
QR182 .H36 2019
Dewey Decimal Classification
616.07/9
Summary
Immunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question "can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?".
Note
Includes index.
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Source of Description
Description based on online resource; title from digital title page (viewed on July 08, 2019).
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Table of Contents
Methods and Models for Studying Immunosenescence
Methods for studying human immunosenescence in tissues other than blood
Mechanisms
Receptors and Signal Transduction
Clinical Relevance in Disease States - Infection
Modulation
Nutrition.
Methods for studying human immunosenescence in tissues other than blood
Mechanisms
Receptors and Signal Transduction
Clinical Relevance in Disease States - Infection
Modulation
Nutrition.