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Intro; Cardiovascular Regenerative Medicine: An Introduction; Contents; Contributors; 1: Tissue-Engineered Stem Cell Models of Cardiovascular Diseases; Introduction; Enabling Technology: Induced Pluripotent Stem Cells; Cardiac Disease Models; Differentiation Protocols; Design Strategies for Engineered Heart Tissue; Hydrogel-Based Engineered Heart Tissues; Fibrous Scaffolds; Engineered Heart Tissue Self-Assembly; Molecular Maturity of Cardiovascular Stem Cell Models; Disease Models of Genetic Cardiac Disorders; Vascular Disease Models; Discussion of Vascular Differentiation Protocols
Derivation of Endothelial Cells (ECs) from hiPSCsDerivation of Vascular Smooth Muscle Cells (VSMCs) from hiPSCs; Tissue-Engineered Models for Vascular Diseases; Summary; Works Cited; 2: Phenotypic Screening of iPSC-Derived Cardiomyocytes for Cardiotoxicity Testing and Therapeutic Target Discovery; Introduction; Addressing Immaturity: How Mature Is Mature Enough?; iPSC-Derived Cardiomyocytes for Disease Modeling and Drug Discovery; iPSC-Derived Cardiomyocytes to Assess Cardiotoxicity; Conclusions and Future Perspectives; References
3: Decellularized Extracellular Matrix-Based Cardiovascular Tissue EngineeringIntroduction; Methods for Decellularization; Decellularization and Characterization of Myocardium and Pericardium; Decellularization of Cardiac Valves; Decellularization of Blood Vessels; Other Decellularization Strategies; Characterization of Decellularized Extracellular Matrix; Crosslinking and Sterilization of Decellularized Extracellular Matrix; Decellularized Extracellular Matrix Formats; Culture Coating; Injectable Materials; Patch; Whole Organ Decellularization; Bioink; Cardiac Applications
Myocardial Application of Cardiac-Derived MatricesMyocardial Application of Noncardiac-Derived Matrices; Myocardial Application of Hybrid Scaffolds; Repair of Cardiac Valves and Blood Vessels; Decellularized Extracellular Matrix in Preclinical and Clinical Trials; Future Outlook; References; 4: 3D Bioprinting of Cardiovascular Tissue Constructs: Cardiac Bioinks; Introduction; Types of Bioinks; Cardiac Bioink Characteristics; Outlook and Conclusions; References; 5: Nanobiomaterial Advances in Cardiovascular Tissue Engineering; Introduction; Advances in Nanobiotechnology
The Heart at the NanoscaleEngineering Nanotopography of Cardiac Tissue Scaffolds; Nanofibrous Scaffolds; Surface Nanostructures; Molecular and Cellular Imprinting; Conductive Nanomaterials; Spherical Conductive Nanomaterials; High-Aspect Ratio Conductive Nanomaterials; Engineering Nanocarriers for Cardiac Tissue Repair; Future Outlook; References; 6: Bioengineering 3D Cardiac Microtissues Using Bioassembly; Introduction; Bioassembly Techniques for 3D Cardiac Microtissues; Acoustic Field-Guided Assembly; Faraday Wave; Surface Acoustic Wave; Magnetic Field-Guided Assembly
Derivation of Endothelial Cells (ECs) from hiPSCsDerivation of Vascular Smooth Muscle Cells (VSMCs) from hiPSCs; Tissue-Engineered Models for Vascular Diseases; Summary; Works Cited; 2: Phenotypic Screening of iPSC-Derived Cardiomyocytes for Cardiotoxicity Testing and Therapeutic Target Discovery; Introduction; Addressing Immaturity: How Mature Is Mature Enough?; iPSC-Derived Cardiomyocytes for Disease Modeling and Drug Discovery; iPSC-Derived Cardiomyocytes to Assess Cardiotoxicity; Conclusions and Future Perspectives; References
3: Decellularized Extracellular Matrix-Based Cardiovascular Tissue EngineeringIntroduction; Methods for Decellularization; Decellularization and Characterization of Myocardium and Pericardium; Decellularization of Cardiac Valves; Decellularization of Blood Vessels; Other Decellularization Strategies; Characterization of Decellularized Extracellular Matrix; Crosslinking and Sterilization of Decellularized Extracellular Matrix; Decellularized Extracellular Matrix Formats; Culture Coating; Injectable Materials; Patch; Whole Organ Decellularization; Bioink; Cardiac Applications
Myocardial Application of Cardiac-Derived MatricesMyocardial Application of Noncardiac-Derived Matrices; Myocardial Application of Hybrid Scaffolds; Repair of Cardiac Valves and Blood Vessels; Decellularized Extracellular Matrix in Preclinical and Clinical Trials; Future Outlook; References; 4: 3D Bioprinting of Cardiovascular Tissue Constructs: Cardiac Bioinks; Introduction; Types of Bioinks; Cardiac Bioink Characteristics; Outlook and Conclusions; References; 5: Nanobiomaterial Advances in Cardiovascular Tissue Engineering; Introduction; Advances in Nanobiotechnology
The Heart at the NanoscaleEngineering Nanotopography of Cardiac Tissue Scaffolds; Nanofibrous Scaffolds; Surface Nanostructures; Molecular and Cellular Imprinting; Conductive Nanomaterials; Spherical Conductive Nanomaterials; High-Aspect Ratio Conductive Nanomaterials; Engineering Nanocarriers for Cardiac Tissue Repair; Future Outlook; References; 6: Bioengineering 3D Cardiac Microtissues Using Bioassembly; Introduction; Bioassembly Techniques for 3D Cardiac Microtissues; Acoustic Field-Guided Assembly; Faraday Wave; Surface Acoustic Wave; Magnetic Field-Guided Assembly