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Cancer stem cell resistance to targeted therapy / Cristina Maccalli, Matilde Todaro, Soldano Ferrone, editors.

Maccalli, Cristina, editor.; Todaro, Matilde, editor.; Ferrone, Soldano, editor.
2019
RC271.C5 C36 2019
Available Online
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Title
Cancer stem cell resistance to targeted therapy / Cristina Maccalli, Matilde Todaro, Soldano Ferrone, editors.
ISBN
9783030166243 (electronic book)
3030166244 (electronic book)
9783030166236
3030166236
DOI
https://doi.org/10.1007/978-3-030-16624-3
https://doi.org/10.1007/978-3-030-16
Published
Cham, Switzerland : Springer, [2019]
Language
English
Description
1 online resource
Item Number
10.1007/978-3-030-16624-3 doi
10.1007/978-3-030-16
Call Number
RC271.C5 C36 2019
Dewey Decimal Classification
614.5999
Summary
This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
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Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Description based on online resource; title from digital title page (viewed on July 18, 2019).
Added Author
Maccalli, Cristina, editor.
Todaro, Matilde, editor.
Ferrone, Soldano, editor.
Series
Resistance to targeted anti-cancer therapeutics ; 19.
Available in Other Form
Print version: 9783030166236
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