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Histone Deacetylase Inhibitors -- Epidrugs for Neurological Disorders / Shabir Ahmad Ganai.

Ganai, Shabir Ahmad.
2019
QC552.H5
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Title
Histone Deacetylase Inhibitors -- Epidrugs for Neurological Disorders / Shabir Ahmad Ganai.
Author
Ganai, Shabir Ahmad.
ISBN
9789811380198 (electronic book)
9811380198 (electronic book)
981138018X
9789811380181
Publication Details
Singapore : Springer, 2019.
Language
English
Description
1 online resource (101 pages)
Item Number
10.1007/978-981-13-8
Call Number
QC552.H5
Dewey Decimal Classification
612.8
Summary
This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors therapeutic efficacy against various neurological complications.
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Histone Deacetylase Inhibitors -- Epidrugs for Neurological Disorders.
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Chapter 1. Role of Epigenetics in neurological diseases
Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens
Chapter 3. Distinct classes of HDACs
Chapter 4. HDAC implications in neurological diseases
Chapter 5. HDAC inhibitors and their structurally distinct groups
Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders
Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies
Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy
Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents
Chapter 10. Future directions of epigenetic research in tackling neurological complications.

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