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Intro; Preface; Contents; An Integrated Transcriptomic, Proteomic, and Metabolomic Approach to Unravel the Molecular Mechanisms of Metal Stress Tolerance in Plants; 1 Introduction; 2 Heavy Metal-Induced Nutritional and Water-Deficit Stresses; 2.1 Nutritional Stress in Metal-Exposed Plants; 2.2 Water Stress in Metal-Exposed Plants; 3 Role of Thiol- and Non-thiol Compounds and Metal(loid) Chelation; 3.1 Phytochelatins and Their Induction; 3.2 Biosynthesis of PCs and Variations (Homo-PCs, Hydroxymethyl-PCs, and Iso-PCs); 3.3 Mode of Action of PCs

3.4 The Superfamily of Metallothioneins: Classification and Structure of Metallothioneins3.5 Expression of MT Genes; 3.6 Metal(loid) Specificity and Chelation; 3.7 Functions of MTs; 4 Heavy Metal Stress Tolerance at Molecular Level: Omics Approach; 4.1 Transcriptomics; 4.2 Proteomics; 4.3 Metabolomics; 5 Conclusions and the Way Forward; References; Molecular Mechanism and Signaling Response of Heavy Metal Stress Tolerance in Plants; 1 Introduction; 2 Heavy Metal Ion Uptake and Translocation; 2.1 Factors Influencing Metal Uptake; 2.2 Sequestration of Heavy Metals and Compartmentalization

3 Heavy Metal-Induced Oxidative Damage in Plants4 Signaling Response Under Heavy Metal Stress; 4.1 Signal Transduction; 4.2 Protein Metabolism; 4.3 Functional Genomics; 4.4 miRNA-Based Regulation; 5 Conclusion and Future Outlook; References; Heavy Metal Toxicity and Plant Productivity: Role of Metal Scavengers; 1 Heavy Metal Toxicity: An Oxidative Challenge; 2 Non-protein Thiols: Key Metabolites in Heavy Metal Scavenging; 3 The Role of Proline and Glycine Betaine in Improving Heavy Metal Stress Tolerance in Plants; 4 Concluding Comments; References

Cadmium (Cd): An Emerging Regulatory Metal with Critical Role in Cell Signalling and Plant Morphogenesis1 Cadmium in Nature; 2 The Uptake and Distribution of Cadmium in Plants; 2.1 Cd in Plant Organs; 2.2 Cd Transporters, Mechanisms of Translocation and Final Distribution; 3 Toxicity to Plants; 3.1 The Impact on Plant Anatomy, Morphogenesis and Development; 3.2 Cd/Zn and Cd/Fe Interactions; 3.3 Can Cd be advantageous to Plants?; 4 Cadmium Signalling; 4.1 ROS, NO and Hormones; 4.2 Ethylene; 4.3 Jasmonic Acid; 4.4 Salicylic Acid; 4.5 Brassinosteroids; 4.6 Abscisic Acid; 4.7 microRNAs

5 ConclusionsLiterature; Heavy Metal Hyperaccumulator Plants: The Resource to Understand the Extreme Adaptations of Plants Towards Heavy Metals; 1 Introduction; 2 Response of Hyperaccumulator to Metals; 2.1 Metal Uptake by Roots of Hyperaccumulator Plants; 2.2 Metal Accumulation in Hyperaccumulator Plants; 2.2.1 Metal-Binding Proteins; 2.2.2 Phytochelatins; 2.2.3 Metal Chelation by Small Molecules; 3 Long-Distance Transport of Metal Ions in Hyperaccumulator Plants; 4 Intracellular Partitioning and Subcellular Transport of Metals in Plants

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