@article{910418,
      author = {Devillers, J.},
      url = {http://library.usi.edu/record/910418},
      title = {Juvenile hormones and juvenoids modeling biological  effects and environmental fate / [electronic resource] :},
      publisher = {CRC Press,},
      abstract = {"Series Introduction The correlation between the toxicity  of molecules and their physicochemical properties can be  traced to the nineteenth century. Indeed, in a French  thesis entitled Action de l'alcool amylique sur l'organisme  (Action of amyl alcohol on the body), which was presented  by A. Cros before the Faculty of Medicine at the University  of Strasbourg in 1863, an empirical relationship was made  between the toxicity of alcohols, their number of carbon  atoms, as well as their solubility. In 1875,  Dujardin-Beaumetz and Audigier the first to stress the  mathematical character of the relationship between the  toxicity of alcohols and their chain length and molecular  weight. In 1899, Hans Horst Meyer and Fritz Baum, at the  University of Marburg, showed that narcosis or hypnotic  activity was in fact linked to the affinity of substances  to water and lipid sites within the organism. At the same  time at the University of Zurich, Ernest Overton came to  the same conclusion providing the foundation of the lipoid  theory of narcosis. The next important step was made in the  1930s by Lazarev in St. Petersburg, who first demonstrated  that different physiological and toxicological effects of  molecules were correlated with their oil- water partition  coefficient through formal mathematical equations in the  following form: log C = a logPoil/water + b. Thus, the  quantitative structure-activity relationship (QSAR)  discipline was born. Its foundations were definitively  fixed in the early 1960s by the seminal works contributed  by C. Hansch and T. Fujita"--},
      recid = {910418},
      pages = {xiii, 381 p., [12] p. of plates :},
      address = {Boca Raton, Fla. :},
      year = {2013},
}