000910418 000__ 03156cam\a2200409\a\4500 000910418 001__ 910418 000910418 005__ 20210515183119.0 000910418 006__ m\\\\\o\\d\\\\\\\\ 000910418 007__ cr\cn\nnnunnun 000910418 008__ 130226s2013\\\\fluaf\\\ob\\\\001\0\eng\d 000910418 010__ $$z 2013007332 000910418 020__ $$z9781466513211 000910418 020__ $$z9781466513228 $$q(electronic book) 000910418 035__ $$a(MiAaPQ)EBC1186507 000910418 035__ $$a(Au-PeEL)EBL1186507 000910418 035__ $$a(CaPaEBR)ebr10699995 000910418 035__ $$a(CaONFJC)MIL501704 000910418 035__ $$a(OCoLC)843642714 000910418 040__ $$aMiAaPQ$$cMiAaPQ$$dMiAaPQ 000910418 050_4 $$aQL494.5$$b.J88 2013 000910418 08204 $$a571.8/76374$$223 000910418 24500 $$aJuvenile hormones and juvenoids$$h[electronic resource] :$$bmodeling biological effects and environmental fate /$$cedited by James Devillers. 000910418 260__ $$aBoca Raton, Fla. :$$bCRC Press,$$c2013. 000910418 300__ $$axiii, 381 p., [12] p. of plates :$$bill. 000910418 4901_ $$aQSAR in environmental and health sciences 000910418 504__ $$aIncludes bibliographical references and index. 000910418 506__ $$aAccess limited to authorized users. 000910418 520__ $$a"Series Introduction The correlation between the toxicity of molecules and their physicochemical properties can be traced to the nineteenth century. Indeed, in a French thesis entitled Action de l'alcool amylique sur l'organisme (Action of amyl alcohol on the body), which was presented by A. Cros before the Faculty of Medicine at the University of Strasbourg in 1863, an empirical relationship was made between the toxicity of alcohols, their number of carbon atoms, as well as their solubility. In 1875, Dujardin-Beaumetz and Audigier the first to stress the mathematical character of the relationship between the toxicity of alcohols and their chain length and molecular weight. In 1899, Hans Horst Meyer and Fritz Baum, at the University of Marburg, showed that narcosis or hypnotic activity was in fact linked to the affinity of substances to water and lipid sites within the organism. At the same time at the University of Zurich, Ernest Overton came to the same conclusion providing the foundation of the lipoid theory of narcosis. The next important step was made in the 1930s by Lazarev in St. Petersburg, who first demonstrated that different physiological and toxicological effects of molecules were correlated with their oil- water partition coefficient through formal mathematical equations in the following form: log C = a logPoil/water + b. Thus, the quantitative structure-activity relationship (QSAR) discipline was born. Its foundations were definitively fixed in the early 1960s by the seminal works contributed by C. Hansch and T. Fujita"--$$cProvided by publisher. 000910418 650_0 $$aInsects$$xMetamorphosis$$xEndocrine aspects. 000910418 650_0 $$aJuvenile hormones. 000910418 650_0 $$aInsect hormones. 000910418 650_0 $$aInsect pests$$xControl$$xEnvironmental aspects. 000910418 7001_ $$aDevillers, J.$$q(James),$$d1956- 000910418 830_0 $$aQSAR in environmental and health sciences. 000910418 852__ $$bebk 000910418 85640 $$3ProQuest Ebook Central Academic Complete$$uhttps://univsouthin.idm.oclc.org/login?url=https://ebookcentral.proquest.com/lib/usiricelib-ebooks/detail.action?docID=1186507$$zOnline Access 000910418 909CO $$ooai:library.usi.edu:910418$$pGLOBAL_SET 000910418 980__ $$aEBOOK 000910418 980__ $$aBIB 000910418 982__ $$aEbook 000910418 983__ $$aOnline